Cetrimonium bromideCetrimonium bromide
MedChemExpress (MCE)
HY-B1260
57-09-0
CTAB
Cetyltrimethylammonium bromide
Hexadecyltrimethylammonium bromide
98.0%
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months
-20°C, 1 month (sealed storage, away from moisture and light)
Room temperature in continental US
may vary elsewhere.
Cetrimonium bromide (CTAB), a quaternary ammonium, is an orally active cationic surfaetant. Cetrimonium bromide has toxicity and anticancer effect. Cetrimonium bromide inhibits cell migration and invasion through modulating the canonical and non-canonical TGF-β signaling pathways. Cetrimonium bromide can be used for DNA extraction.
Cetrimonium bromide (1-5 μM, 24 h) cannot affect growth of SK-HEP-1 cells[1]. Cetrimonium bromide (5 μM, 16-24 h) attenuates cellular migration and invasion of SK-HEP-1cells[1]. Cetrimonium bromide (5 μM, 24 h) inhibits the protein expression of MMP-2 and MMP-9, increases the protein expression of TIMP-1 and TIMP-2 and restrain the protein expression of Rac1, cdc42 and RhoA in SK-HEP-1cells[1]. Cetrimonium bromide (5 μM, 12-72 h) induces apoptosis in human Head and neck cancer (HNC) cells[2].
Cetrimonium bromide (5 mg/kg, Intraperitoneal injection, once a day for five consecutive days) ablated tumor-forming capacity of FaDu cells and delayed growth of established tumors in FaDu cells tumor-bearing mice[2]. Cetrimonium bromide (10-45 mg/kg, Supplemented in drinking water, once a day for 1 year) has subacute and chronic toxicity in the rat[3].
MMP-9 MMP-2
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[1]. Wu T K, et al. Cetrimonium bromide inhibits cell migration and invasion of human hepatic SK-HEP-1 cells through modulating the canonical and non-canonical TGF-β signaling pathways [J]. Anticancer research, 2019, 39(7): 3621-3631. [Content Brief]
[2]. Ito E, et al. Potential use of cetrimonium bromide as an apoptosis-promoting anticancer agent for head and neck cancer [J]. Molecular pharmacology, 2009, 76(5): 969-983. [Content Brief]
[3]. Isomaa B, et al. The subacute and chronic toxicity of cetyltrimethylammonium bromide (CTAB), a cationic surfactant, in the rat [J]. Archives of toxicology, 1976, 35: 91-96. [Content Brief]
[4]. Allen G C, et al. A modified protocol for rapid DNA isolation from plant tissues using cetyltrimethylammonium bromide [J]. Nature protocols, 2006, 1(5): 2320-2325. [Content Brief]