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  6. 4-Chloro-DL-phenylalanine; PCPA; CP-10188

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Supplier Contact

Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
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Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
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Product Name4-Chloro-DL-phenylalanine
SynonymsNSC-77370
Fenclonine
H-DL-Phe(4-Cl)-OH
DL-4-Chloro-phe-OH
4-chlorophenylalanine
Phenylalanine, 4-chloro-
Dl-4-Chlorophenylalanine

Synonyms

NSC-77370
Fenclonine
H-DL-Phe(4-Cl)-OH
DL-4-Chloro-phe-OH
4-chlorophenylalanine
Phenylalanine, 4-chloro-
Dl-4-Chlorophenylalanine
4-Chloro-DL-phenylalanine
DL-Phe(4-Cl)-OH 4-Chloro-DL-Phenylalanine
(±)-3-(4-Chlorophenyl)-2-aminopropanoic acid
DL-2-Amino-3-(4-chloro-phenyl)-propionic acid
H-4-Chloro-DL-Phe-OH, (RS)-2-AMino-3-(4-chloro-phenyl)-propionic acid, Fenclonine, PCPA
CAS7424-00-2
EINECS231-051-9
Chemical FormulaC9H10ClNO2
Molecular Weight199.63
inchiInChI=1/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
Package10 mM * 1 mL;500 mg;1 g
PriceEmail to quote
DescriptionsFenclonine

Fenclonine

MedChemExpress (MCE)

HY-B1368

7424-00-2

4-Chloro-DL-phenylalanine

Descriptions

Fenclonine

Fenclonine

MedChemExpress (MCE)

HY-B1368

7424-00-2

4-Chloro-DL-phenylalanine
PCPA
CP-10188

99.92%

Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Room temperature in continental US
may vary elsewhere.

Fenclonine is a selective and irreversible tryptophan hydroxylase inhibitor, which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine can be used in carcinoid syndrome research.

Fenclonine can be used in animal modeling to create insomnia models[4]. .f12{ font-size: 12px
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} 1. Induction of insomnia[4] Background Fenclonine can inhibit the synthesis of serotonin (5-HT), induce 5-HT depletion, and lead to insomnia. Specific Mmodeling Methods Rat: Sprague-Dawley (SD) • male • 6-8 weeks oldAdministration: 300 mg/kg • i.p. • once daily for 3 days Note Start injecting Fenclonine three days after administration. Modeling Indicators Molecular changes: Downregulation of 5-HT1AR expression. Correlated Product(s): / Opposite Product(s): Buspirone (HY-B1115A)

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[1]. M Jouvet. Sleep and serotonin: an unfinished story. Neuropsychopharmacology. 1999 Aug
21(2 Suppl):24S-27S. [Content Brief]

[2]. A K Sanyal, et al. Prostaglandins: antinociceptive effect of prostaglandin E1 in the rat. Clin Exp Pharmacol Physiol. 1977 May-Jun
4(3):247-55. [Content Brief]

[3]. Shyamshree S S Manna, et al. Paracetamol potentiates the antidepressant-like and anticompulsive-like effects of fluoxetine. Behav Pharmacol. 2015 Apr
26(3):268-81. [Content Brief]

[4]. Zheng Y, et al. In silico Analysis and Experimental Validation of Lignan Extracts from Kadsura longipedunculata for Potential 5-HT1AR Agonists. PLoS One. 2015 Jun 15
10(6):e0130055. [Content Brief]

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