Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride MedChemExpress (MCE)

Product Name	Nortriptyline hydrochloride
Synonyms	Vividyl Sensival Norzepine Norfenazin NORTRIPTYLINE HCL(P) Nortriptyline hydrochloride Nortriptyline hydrochloride solution Synonyms Vividyl Sensival Norzepine Norfenazin NORTRIPTYLINE HCL(P) Nortriptyline hydrochloride Nortriptyline hydrochloride solution Nortriptyline Hydrochloride (200 mg) AMITRIPTYLINE EP IMPURITY C HCL (NORTRIPTYLINE HCL)
CAS	894-71-3
EINECS	212-973-0
Chemical Formula	C19H22ClN
Molecular Weight	299.84
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Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg;200 mg;500 mg;1 g
Price	Email to quote
Descriptions	Nortriptyline hydrochloride Nortriptyline hydrochloride MedChemExpress (MCE) HY-B1417 894-71-3 Desmethylamitriptyline hydrochloride Descriptions Nortriptyline hydrochloride Nortriptyline hydrochloride MedChemExpress (MCE) HY-B1417 894-71-3 Desmethylamitriptyline hydrochloride Desitriptilina hydrochloride 99.98% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects. Amitriptyline is metabolized by CYP2C19 to the active metabolite, Nortriptyline. Nortriptyline blocks the reuptake of Norepinephrine more potently than Serotonin[1]. Nortriptyline (6.25-100 μM 24-72 h) hydrochloride markedly reducs the viability of TCCSUP and mouse MBT-2 bladder cancer cells in a concentration- and time-dependent manner[3]. Nortriptyline (12.55-100 μM 24 h) hydrochloride induces cell cycle arrest and apoptosis in TCCSUP and MBT-2 cells[3]. Nortriptyline (12.55-100 μM 24 h) hydrochloride induces both intrinsic and extrinsic apoptosis in these bladder cancer cells[3]. Nortriptyline (10-20 mg/kg ip every day for three weeks) hydrochloride inhibits the growth of bladder tumors in mice inoculated with MBT-2 cells[3]. \| \| \| \| \| \| \| \| \| \| [1]. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US) 2012-2017 Mar 23. [Content Brief]* [2]. Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022 10.1002/ijc.33965. [Content Brief] [3]. Sheau-Yun Yuan, et al. Nortriptyline induces mitochondria and death receptor-mediated apoptosis in bladder cancer cells and inhibits bladder tumor growth in vivo. Eur J Pharmacol. 2015 Aug 15:761:309-20. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Nortriptyline-hydrochloride.html
Last Update	2025-05-21 16:50:25

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