Endoxifen (Z-isomer) MedChemExpress (MCE)

Product Name	Endoxifen
Synonyms	Endoxifen (Z)-Endoxifen (Z)-4-Hydroxy-N-desmethyl Tamoxifen (Z)-4-Hydroxy-N-DesMethyl TaMoxifen (Endoxifen) Phenol, 4-[(1Z)-1-[4-[2-(MethylaMino)ethoxy]phenyl]-2-phenyl-1-butenyl]- 4-[(1Z)-1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
CAS	112093-28-4
EINECS
Chemical Formula	C25H27NO2
Molecular Weight	373.49
inchi
Package	5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	Endoxifen (Z-isomer) Endoxifen (Z-isomer) MedChemExpress (MCE) HY-18719 112093-28-4 99.20% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Endoxifen (Z-isomer) Endoxifen (Z-isomer) MedChemExpress (MCE) HY-18719 112093-28-4 99.20% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Endoxifen Z-isomer is an oral active Tamoxifen (HY-13757A) metabolite, inducing an anti-estrogenic effect in breast cancer cells expressing ERα. Endoxifen Z-isomer inhibits hERG. This effect is concentration-dependent, with an IC50 value of 1.6 μM. Z-Endoxifen (Z-isomer) (0.1-5 μM, 7 days) exhibits potent antiproliferative activity against MCF7AC1 and MCF7LR cell lines[4]. Z-Endoxifen (Z-isomer) (5 mg/kg/day, s.c., gradual drug release every 30 days, pellets replaced every 90 days) effectively prevents breast cancer in the C3(1)-TAg mouse model[3]. Z-Endoxifen (50 mg/kg, p.o., 5 times a week for 4 weeks) shows better antitumor efficacy in the MCF7LR resistant mouse model[4]. Z-Endoxifen (75 mg/kg, p.o., once daily for 4 weeks) shows strong antitumor activity in the MCF7AC1 mouse breast cancer model[4]. \| \| \| \| \| \| \| \| \| \| [1]. Chae YJ, et al. Endoxifen, the active metabolite of tamoxifen, inhibits cloned hERG potassium channels. Eur J Pharmacol. 2015 Apr 5 752:1-7. [Content Brief] [2]. Wu X, et al. Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. Breast Cancer Res. 2011 Mar 10 13(2):R27. [Content Brief] [3]. Lee O, et al. Z-Endoxifen prevents aggressive mammary cancers in mice by inhibiting cell proliferation and creating a tumor suppressive microenvironment. Biomed Pharmacother. 2023 Jun 162:114607. [Content Brief] [4]. Jayaraman S, et al. Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer. Breast Cancer Res. 2020 May 19 22(1):51. [Content Brief]
Last Update	2025-04-01 14:45:47

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