WEHI-345 MedChemExpress (MCE)

Product Name	WEHI-345
Synonyms	WEHI345 CS-2140 WHI-345 WEHI 345 WEHI-345 N-[2-[4-Amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]-4-pyridinecarboxamide 4-Pyridinecarboxamide, N-[2-[4-amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]-
CAS	1354825-58-3
EINECS
Chemical Formula	C22H23N7O
Molecular Weight	401.46
inchi
Package	10 mM * 1 mL;2 mg;5 mg;10 mg
Price	Email to quote
Descriptions	WEHI-345 WEHI-345 MedChemExpress (MCE) HY-18937 1354825-58-3 99.31% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions WEHI-345 WEHI-345 MedChemExpress (MCE) HY-18937 1354825-58-3 99.31% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation. WEHI-345 (500 nM Raw 267.4 cells) is able to inhibit MDP-induced autophosphorylation activity of RIPK2 in cells[1]. WEHI-345 (500 nM 0 hour, 2 hours, 4 hours, 8 hours BMDMs or THP-1 cells) potently blocks MDP-induced transcription of the inflammatory mediators TNF and interleukin-6 (IL-6) in bone marrow-derived macrophages (BMDMs). In THP-1 cells, WEHI-345 reduces mRNA levels of NF-kB targets such as TNF, IL-8, IL-1b and A20[1]. WEHI-345 (20 mg/kg intraperitoneal injection twice daily for 6 days C57BL/6 male mice) treatment reduces disease score, inflammatory infiltrate, histological score and recruitment of dendritic cells to the site of inflammation. And improves body weight and reduces cytokine and chemokine levels, indicating an overall improvement of the condition in experimental autoimmune encephalomyelitis (EAE)-induced wild-type C57Bl/6 mice[1]. RIPK2 \| \| \| \| \| \| \| \| \| \| [1]. Nachbur U, et al. A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production. Nat Commun. 2015 Mar 17 6:6442. [Content Brief]
Last Update	2025-04-01 14:45:47

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