Tolmetin sodium dihydrate MedChemExpress (MCE)

Product Name	tolmetin sodium dihydrate
Synonyms	TOLMELINSODIUM Tolmetin Sodium tolmetinsodiumdihydrate sodiumtolmetindihydrate tolmetin sodium dihydrate Sodium tolmetin dihydrate Tolmetinsodiumsaltdihydratecrystalline Synonyms TOLMELINSODIUM Tolmetin Sodium tolmetinsodiumdihydrate sodiumtolmetindihydrate tolmetin sodium dihydrate Sodium tolmetin dihydrate Tolmetinsodiumsaltdihydratecrystalline 1-Methyl-5-p-toluoylpyrrole-2-acetic Acid Sodium Dihydrate 5-[(p-Tolyl)carbonyl]-1-methylpyrrole-2-acetic Acid Sodium Dihydrate 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic Acid Sodium Dihydrate 1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium-potassium salt dihydrate 1H-pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt, dihydrate
CAS	64490-92-2
EINECS	626-708-5
Chemical Formula	C15H14NO3.Na.2H2O
Molecular Weight	315.3
inchi	InChI=1/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;
Package	10 mM * 1 mL;100 mg
Price	Email to quote
Descriptions	Tolmetin sodium dihydrate Tolmetin sodium dihydrate MedChemExpress (MCE) HY-B1489 64490-92-2 99.94% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Tolmetin sodium dihydrate Tolmetin sodium dihydrate MedChemExpress (MCE) HY-B1489 64490-92-2 99.94% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Tolmetin sodium dihydrate is an orally active and potent COX inhibitor with IC50s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin sodium dihydrate is a non-steroidal anti-inflammatory drug (NSAID). Tolmetin sodium dihydrate (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat[3]. Tolmetin sodium dihydrate (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner[4]. Tolmetin sodium dihydrate (0-100 μM) shows no effect on osteoblast growth[5]. Tolmetin sodium dihydrate (30,100 mg/kg gavage single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg[2]. Tolmetin sodium dihydrate (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity[3]. Rats[1] After 2 weeks of acclimatization, rats are randomized to different groups and given the non-selective COX inhibitors, amtolmetin guacyl (AMG) (50 and 150 mg/kg) and Tolmetin (30 and 100 mg/kg) as well as the selective COX-2 inhibitor, celecoxib (CXIB 20 and 60 mg/kg). The compounds are suspended in 1% carboxymethylcellulose (CMC) immediately before use and administered by gavage in a 10-mL/kg volume. Control groups receive CMC in the same volume. Rats from each group are divided into 3 subgroups, consisting each of at least 10 animals. Subgroups are dosed either with a single dose (acute treatment group) or twice daily for 3 and 14 days (chronic treatment groups). To ensure that all groups are dosed for the same period of time, those receiving less than 14 days of NSAIDs are given CMC until they are due to start the assigned treatment. Rats are killed by cervical dislocation 4 h after the last administration. Stomachs are immediately removed, opened along the lesser curvature and gently rinsed[1]. Human COX-1 0.35 μM (IC50) Human COX-2 0.82 μM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. T D Warner, et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci U S A. 1999 Jun 22 96(13):7563-8. [Content Brief] [2]. Morini G, et al. Morphological features of rat gastric mucosa after acute and chronic treatment with amtolmetin guacyl: comparison with non-selective and COX-2-selective NSAIDs. Digestion. 2003 68(2-3):124-32. Epub 2003 Nov 7. [Content Brief] [3]. Dairam A, et al. Non-steroidal anti-inflammatory agents, tolmetin and sulindac, attenuate oxidative stress in rat brain homogenate and reduce quinolinic acid-induced neurodegeneration in rat hippocampal neurons. Metab Brain Dis. 2006 Sep 21(2-3):221-33. [Content Brief] [4]. DADAŞ, Yakup, et al. Synthesis and anticancer activity of some novel tolmetin thiosemicarbazides. Marmara Pharmaceutical Journal 19(3) • April 2015 [5]. Etcheverry SB, et al. Three new vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen and Tolmetin). Bioactivity on osteoblast-like cells in culture. J Inorg Biochem. 2002 Jan 1 88(1):94-100. [Content Brief]
Last Update	2025-04-01 14:45:47

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