DASA-58 MedChemExpress (MCE)

Product Name	DASA-58
Synonyms	DASA58 DASA-58 CS-1563 DASA 58 3-[[4-[(2,3-Dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]benzenamine Benzenamine, 3-[[4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]-
CAS	1203494-49-8
EINECS
Chemical Formula	C19H23N3O6S2
Molecular Weight	453.53
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	DASA-58 DASA-58 MedChemExpress (MCE) HY-19330 1203494-49-8 99.73% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions DASA-58 DASA-58 MedChemExpress (MCE) HY-19330 1203494-49-8 99.73% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. DASA-58 is a potential pyruvate kinase isozyme (PKM2) allosteric activator. DASA-58 can be used for the research of metabolism and kinds of cancer. DASA-58 (15 μM 2 h) potentiates the antitumor effects of other metabolic stressors[1].?DASA-58 (15 μM 24 h, 72 h) enhances pyruvate kinase activity in breast cancer cells without a clear effect on proliferation[1].?DASA-58 (30 μM, 60 μM 0-72 h) enhances extracellular acidification and lactate levels in BCa cell lines and induce extracellular acidification levels in prostate cancer cell lines[1].?DASA-58 (15 μM, 30 μM 0-72 h) affects respiration levels in BCa cells without an indication of mitochondrial damage[1].?DASA-58 (15 μM 0-72 h) not rescues TXNIP levels in any combintion and mitochondrial inhibitors enhance PKM2 effects on activating AMPK signaling (T172 phosphorylation of AMPK) [1].?DASA-58 (15 μM 0-72 h) leads to depletion in TXNIP levels independent of? AMPK and ER signaling, and not through enhanced? proteasomal degradation but rather depleted upstream glycolytic intermediates[1]. \| \| \| \| \| \| \| \| \| \| [1]. Fadi Almouhanna, et al. Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells. Cancer Metab. 2021 Jan 22 9(1):5. [Content Brief]
Last Update	2025-04-01 14:45:47

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