GBT 440 MedChemExpress (MCE)

Product Name	Voxelotor
Synonyms	GBT 440 OXBRYTA Voxelotor Hemoglobin Modulators-1 Voxelotor(GBT440, GTX011) Voxelotor, GBT-440, GBT 440, GBT440, GTx-011, GTx011, GTx 011 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde Synonyms GBT 440 OXBRYTA Voxelotor Hemoglobin Modulators-1 Voxelotor(GBT440, GTX011) Voxelotor, GBT-440, GBT 440, GBT440, GTx-011, GTx011, GTx 011 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde 2-Hydroxy-6-{[2-(1-isopropyl-1H-pyrazol-5-yl)-3-pyridinyl]methoxy}benzaldehyde 2-hydroxy-6-([2-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-3-yl]methoxy)benzaldehyde
CAS	1446321-46-5
EINECS
Chemical Formula	C19H19N3O3
Molecular Weight	337.3725
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg;200 mg
Price	Email to quote
Descriptions	Voxelotor Voxelotor MedChemExpress (MCE) HY-18681 1446321-46-5 GBT 440 99.99% 4°C, stored under nitrogen In solvent : -80°C, 1 year Descriptions Voxelotor Voxelotor MedChemExpress (MCE) HY-18681 1446321-46-5 GBT 440 99.99% 4°C, stored under nitrogen In solvent : -80°C, 1 year -20°C, 6 months (stored under nitrogen) Room temperature in continental US may vary elsewhere. Voxelotor (GBT 440) is a potent inhibitor of haemoglobin S (HbS) polymerization. Voxelotor has the potential for sickle cell disease (SCD) treatment. Voxelotor (GBT440) binds to the N-terminal a chain of haemoglobin (Hb), increases haemoglobin S (HbS) affinity for oxygen, delays in vitro HbS polymerization and prevents sickling of red blood cells (RBCs)[1]. Voxelotor (GBT440 100-150 mg/kg administered twice a day by oral gavage for 9-12 days) reduces ex vivo sickling and prolongs red blood cells (RBCs) half-life in a murine model of sickle cell disease (SCD)[1].?Voxelotor shows T1/2s of 11.7, 19.1±1.5, 66.0±11, 28.8±4.0 hours for mouse (70 mg/kg i.v.), rat (1.6 mg/kg i.v.), dog (1 mg/kg i.v.), and momkey (1 mg/kg i.v.), respectively[1].?Voxelotor shows Cmaxs of 81.9, 71.2±6.0, 5.56±1.6, and 25.2±5.5 μg/mL for mouse (30 mg/kg p.o.), rat (7.2 mg/kg p.o.), dog (2.5 mg/kg p.o.), and momkey (4.25 mg/kg p.o.), respectively[1]. HbS polymerization[1] In Vitro Voxelotor (GBT440) binds to the N-terminal a chain of haemoglobin (Hb), increases haemoglobin S (HbS) affinity for oxygen, delays in vitro HbS polymerization and prevents sickling of red blood cells (RBCs)[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Voxelotor Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Oksenberg D, et al. GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease. Br J Haematol. 2016 Oct 175(1):141-53. [Content Brief] [2]. Metcalf B, Chuang C, Dufu K, et al. Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. ACS Med Chem Lett. 2017 8(3):321-326. [Content Brief]
Last Update	2025-04-01 14:45:47

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