SGC707 MedChemExpress (MCE)

Product Name	SGC707
Synonyms	SGC707;SGC 707;CS-2192;N-6-Isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea;Urea, N-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-
CAS	1687736-54-4
EINECS
Chemical Formula	C16H18N4O2
Molecular Weight	298.34
inchi
Package	10 mM * 1 mL;500 mg;1 mg;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	SGC707 SGC707 MedChemExpress (MCE) HY-19715 1687736-54-4 98.08% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions SGC707 SGC707 MedChemExpress (MCE) HY-19715 1687736-54-4 98.08% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. SGC707 is a potent, selective, and non-competitive PRMT3 (protein arginine methyltransferase 3) inhibitor (IC50=31 nM, Kd=53 nM). SGC707 (0-10 μM 6 h) binds to PRMT3 in both HEK293 and A549 cells[1]. SGC707 (intraperitoneal injection 10 mg/kg 3 times per week 3 w) treatment reduces hepatic steatosis and plasma triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice[2]. PRMT3 31 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Kaniskan HÜ, et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew Chem Int Ed Engl. 2015 Apr 20 54(17):5166-70. [Content Brief] [2]. de Jong LM, et al. PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice. Sci Rep. 2022 Jan 10 12(1):483. [Content Brief]
Last Update	2025-04-01 14:45:47

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