3PO MedChemExpress (MCE)

Product Name	3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
Synonyms	3 PO 3-PO (E)-3PO inhibitor of glucose metabolism 3PO (inhibitor of glucose metabolism) (E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one Synonyms 3 PO 3-PO (E)-3PO inhibitor of glucose metabolism 3PO (inhibitor of glucose metabolism) (E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one 2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-, (2E)-
CAS	18550-98-6
EINECS
Chemical Formula	C13H10N2O
Molecular Weight	210.23
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg;200 mg
Price	Email to quote
Descriptions	3PO 3PO MedChemExpress (MCE) HY-19824 18550-98-6 99.56% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions 3PO 3PO MedChemExpress (MCE) HY-19824 18550-98-6 99.56% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. 3PO is an inhibitor of PFKFB3. 3PO attenuates the proliferation of several cancer cell lines with IC50s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+ and NADH. 3PO can be used for the research of cancer. 3PO (0-33 μM 0-36 h) inhibits Jurkat cells proliferation by influence cell cycle[1]. 3PO (10 μM/L 0-36 h) suppresses glycolytic flux to lactate in Jurkat cells[1]. 3PO (10 μM/L 0-36 h) inhibits cellular proliferation of transformed tumor cell lines[1]. 3PO (0.07 mg/g i.p. once per day for 14 days) inhibits the growth of Lewis lung carcinoma xenografts in C57Bl/6 mice[1]. 3PO (0.07 mg/g i.p. three sequential daily injections followed by 3 off days for 14 days) inhibits the tumor growth in BALB/c athymic mice[1]. 3PO (0.07 mg/g i.p. two daily injections followed a 7-day rest for 14 days) inhibits the tumor growth in BALB/c athymic mice[1]. 3PO (0.07 mg/g i.p. once) inhibits Fru-2,6-BP and glucose uptake in C57Bl/6 mice[1]. \| \| \| \| \| \| \| \| \| \| [1]. Clem B, et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol Cancer Ther. 2008 Jan 7(1):110-20. [Content Brief] [2]. Schoors S, et al. Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 2014 Jan 7 19(1):37-48. [Content Brief] [3]. Lea MA, Inhibition of Growth of Bladder Cancer Cells by 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one in Combination with Other Compounds Affecting Glucose Metabolism. Anticancer Res. 2015 Nov 35(11):5889-99. [Content Brief]
Supplier Website	https://www.medchemexpress.com/3PO.html
Last Update	2025-04-01 14:45:47

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