NSC348884 MedChemExpress (MCE)

Product Name	NSC348884
Synonyms	CS-2168 NSC348884 NSC 348884 NSC-348884 N1,N1,N2,N2-Tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine 1,2-Ethanediamine, N1,N1,N2,N2-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]- Synonyms CS-2168 NSC348884 NSC 348884 NSC-348884 N1,N1,N2,N2-Tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine 1,2-Ethanediamine, N1,N1,N2,N2-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]- 1,2-EthanediaMine, N,N,N',N'-tetrakis[(5-Methyl-1H-benziMidazol-2-yl)Methyl]- (9CI)
CAS	81624-55-7
EINECS
Chemical Formula	C38H40N10
Molecular Weight	636.79
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	NSC348884 NSC348884 MedChemExpress (MCE) HY-13915 81624-55-7 98.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions NSC348884 NSC348884 MedChemExpress (MCE) HY-13915 81624-55-7 98.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. NSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC50s of 1.7-4.0 μM in distinct cancer cell lines. NSC348884 can be used for the research of cancer. NSC348884 (0-6 μM 24 h) binds with NPM and disrupts NPM oligomer formation[1]. NSC348884 (0.01-100 μM 4 d) shows cytotoxicity to cancer cells[1]. NSC348884 (1 μM 4 d) shows cytotoxicity to mantle cell lymphoma with 0.1 nM doxorubicin[1]. NSC348884 (1-5 μM 24 h) induces cell apoptosis[1]. NSC348884 (0-5 μM 0-24 h) upregulates the concentration of p53[1]. NSC348884 (50 μg i.p. once) reduces tumor growth[2]. IC50: 4 μM (LNCaP cells), 1.7 μM (Granta cells)[1] In Vitro NSC348884 (0-6 μM 24 h) binds with NPM and disrupts NPM oligomer formation[1]. NSC348884 (0.01-100 μM 4 d) shows cytotoxicity to cancer cells[1]. NSC348884 (1 μM 4 d) shows cytotoxicity to mantle cell lymphoma with 0.1 nM doxorubicin[1]. NSC348884 (1-5 μM 24 h) induces cell apoptosis[1]. NSC348884 (0-5 μM 0-24 h) upregulates the concentration of p53[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NSC348884 Related Antibodies Cell Viability Assay[1] Cell Line: LNCaP and Granta cell lines \| \| \| \| \| \| \| \| \| \| [1]. Qi W, et al. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancercells. Oncogene. 2008 Jul 10 27(30):4210-20. [Content Brief] [2]. Lin Y, et al. Inhibition of nucleophosmin/B23 sensitizes ovarian cancer cells to antiprogrammed cell death protein-1 ligand therapy. 2022.
Last Update	2025-04-01 14:45:47

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