CP-544326 MedChemExpress (MCE)

Product Name	Taprenepag
Synonyms	CP544326 CP-544326 CP 544326 TAPRENEPAG Taprenepag PF 04217329 CP544326 (Taprenepag) Synonyms CP544326 CP-544326 CP 544326 TAPRENEPAG Taprenepag PF 04217329 CP544326 (Taprenepag) Taprenepag(CP-544326) 2-[3-[[(4-pyrazol-1-ylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]phenoxy]acetic Acid 2-[3-[[[[4-(1H-Pyrazol-1-yl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]phenoxy]acetic acid
CAS	752187-80-7
EINECS
Chemical Formula	C24H22N4O5S
Molecular Weight	478.52
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Taprenepag Taprenepag MedChemExpress (MCE) HY-14899 752187-80-7 CP-544326 98.79% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Taprenepag Taprenepag MedChemExpress (MCE) HY-14899 752187-80-7 CP-544326 98.79% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Taprenepag (CP-544326) is a potent and selective prostaglandin EP(2) agonist with IC50s of 10 and 15 nM for human and rat EP2, respectively. Taprenepag shows selectivity for EP2 over other EP receptors (IC50s>3200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors. Taprenepag (CP-544326) (0.01-1000 nM) increases cAMP levels in HEK293 cells expressing human EP2 (EC50=2.8 nM). Taprenepag has poor corneal permeability in an ex vivo rabbit corneal model[1]. \| \| \| \| \| \| \| \| \| \| [1]. Prasanna G, et al. Effect of PF-04217329 a prodrug of a selective prostaglandin EP(2) agonist on intraocular pressure inpreclinical models of glaucoma. Exp Eye Res. 2011 Sep 93(3):256-64. [Content Brief]
Last Update	2025-04-01 14:45:47

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