CBR-5884 MedChemExpress (MCE)

Product Name	CBR-5884
Synonyms	CBR5884 CBR-5884 CBR 5884 ethyl 4-(cyanosulfanyl)-5-(furan-2-amido)-3-methylthiophene-2-carboxylate Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate 2-Thiophenecarboxylic acid, 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-, ethyl ester
CAS	681159-27-3
EINECS
Chemical Formula	C14H12N2O4S2
Molecular Weight	336.39
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	CBR-5884 CBR-5884 MedChemExpress (MCE) HY-100012 681159-27-3 98.56% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions CBR-5884 CBR-5884 MedChemExpress (MCE) HY-100012 681159-27-3 98.56% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. CBR-5884 (15 or 30 μM 3-5 days) selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. PHGDH, serine synthesis[1] In Vitro CBR-5884 (15 or 30 μM 3-5 days) selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CBR-5884 Related Antibodies Cell Proliferation Assay[1] Cell Line: Breast and melanoma cell lines \| \| \| \| \| \| \| \| \| \| [1]. Edouard Mullarky et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers Proc Natl Acad Sci U S A, 2016 Feb 16, 113(7):1778-83. [Content Brief]
Last Update	2025-04-01 14:45:47

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