CP21 MedChemExpress (MCE)

Product Name	CP21R7
Synonyms	CP21R7 CS-2352 CP21R7(CP21) CP21 (CP21R7) 3-(3-Aminophenyl)-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione 3-(3-aminophenyl)-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Synonyms CP21R7 CS-2352 CP21R7(CP21) CP21 (CP21R7) 3-(3-Aminophenyl)-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione 3-(3-aminophenyl)-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 1H-Pyrrole-2,5-dione, 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-
CAS	125314-13-8
EINECS
Chemical Formula	C19H15N3O2
Molecular Weight	317.34
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	CP21R7 CP21R7 MedChemExpress (MCE) HY-100207 125314-13-8 CP21 99.63% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions CP21R7 CP21R7 MedChemExpress (MCE) HY-100207 125314-13-8 CP21 99.63% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. CP21R7 is potent GSK-3β inhibitor, with an IC50 of 1.8 nM CP21R7 also shows inhibitory activitiy against PKCα, with an IC50 of 1900 nM. CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM the IC50 of CP21R7 against PKCα is 1900 nM[1]. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm[2]. GSK-3β 1.8 nM (IC50) PKCα 1900 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Gong L, et al. Discovery of potent and bioavailable GSK-3beta inhibitors. Bioorg Med Chem Lett. 2010 Mar 1 20(5):1693-6. [Content Brief] [2]. Patsch C, et al. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015 Aug 17(8):994-1003. [Content Brief]
Last Update	2025-04-01 14:45:47

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