(RS)-Alprenolol; dl-Alprenolol MedChemExpress (MCE)

Product Name	Alprenolol
Synonyms	Alprenolol
CAS	13655-52-2
EINECS
Chemical Formula	C15H23NO2
Molecular Weight	249.35
inchi
Package	50 mg;100 mg
Price	Email to quote
Descriptions	Alprenolol Alprenolol MedChemExpress (MCE) HY-B1517 13655-52-2 (RS)-Alprenolol Descriptions Alprenolol Alprenolol MedChemExpress (MCE) HY-B1517 13655-52-2 (RS)-Alprenolol dl-Alprenolol 99.94% Powder -20°C 3 years 4°C 2 years The compound is unstable in solutions, freshly prepared is recommended. Room temperature in continental US may vary elsewhere. Alprenolol ((RS)-Alprenolol dl-Alprenolol) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent. Alprenolol (p.o., 50 mg/kg) causes a significant drop in blood pressure which averages 20 mm Hg (at 3-hr) and an increase in heart rate by 39 beats/min (at 3-hr) in conscious renal hypertensive dogs[1]. Alprenolol (i.p., 5 mg/kg) effectively blockes the anxiolytic effects of indorenate and ipsapirone but do not reduce the motor activity in adult male Swiss Webster mice[2]. Alprenolol (intravenous injection, 0.5 or 1.0 mg/kg) can decrease systolic pressure by a mean of 10 mm Hg, diastolic pressure by a mean of 10 mm Hg) and heart rate by 23 beats/min, as well as slightly reduce both myocardial and liver blood flows by mean of 17% and 15% respectively at a dose of 1.0 mg/kg in cats[3]. 5-HT1A Receptor \| \| \| \| \| \| \| \| \| \| [1]. Himori N, et al. Effects of beta-adrenoceptor blocking agents, pindolol, alprenolol and practolol on blood pressure and heart rate in conscious renal hypertensive dogs. Arch Int Pharmacodyn Ther. 1977 Jan 225(1):152-65. [Content Brief]* [2]. Fernández-Guasti A, et al. Evidence for the involvement of the 5-HT1A receptor in the anxiolytic action of indorenate and ipsapirone. Psychopharmacology (Berl). 1990 101(3):354-8. [Content Brief] [3]. Parratt JR, et al. Myocardial and haemodynamic effects of the beta-adrenoceptor blocking drug alprenolol (H56/28) in anaesthetized cats. Br J Pharmacol. 1969 Oct 37(2):357-66. [Content Brief]
Last Update	2025-04-01 14:45:47

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