A-804598 MedChemExpress (MCE)

Product Name	A-804598
Synonyms	CS-2234 A 804598 A-804598 1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine 1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE 2-Cyano-1-[(1S)-1-phenylethyl]-3-(5-quinolinyl)guanidine Synonyms CS-2234 A 804598 A-804598 1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine 1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE 2-Cyano-1-[(1S)-1-phenylethyl]-3-(5-quinolinyl)guanidine N-Cyano-N′′-[(1S)-1-phenylethyl]-N′-5-quinolinyl-guanidine Guanidine, N-cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-
CAS	1125758-85-1
EINECS
Chemical Formula	C19H17N5
Molecular Weight	315.37
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	A-804598 A-804598 MedChemExpress (MCE) HY-100483 1125758-85-1 98.55% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions A-804598 A-804598 MedChemExpress (MCE) HY-100483 1125758-85-1 98.55% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. A-804598 is a CNS penetrant, competitive and selective P2X7 receptor antagonist with IC50s of 9 nM, 10 nM and 11 nM for mouse, rat and human P2X7 receptors, respectively. Pre-incubation with A-804598 (0.1-10 μM 1 hour) significantly attenuates BzATP-induced cell loss in a concentration-dependent manner. 3 μM A-804598 exhibits the greatest protective effect against BzATP-induced cytotoxicity[2]. A chroni treatment with A-804598 (intraperitoneal injection 30 mg/kg five times a week) decreases the expression of LC3B-II and SQSTM1/p62 in lumbar spinal cord at end stage of disease[3]. P2X7 Receptor \| \| \| \| \| \| \| \| \| \| [1]. Donnelly-Roberts DL et al. [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors. Neuropharmacology, 2009 Jan, 56(1):223-9. [Content Brief] [2]. Yingbo He et al. The role of microglial P2X7: modulation of cell death and cytokine release. Neuroinflammation, 2017 Jul, 14(1):135. [Content Brief] [3]. Paola Fabbrizio et al. P2X7 Receptor Activation Modulates Autophagy in SOD1-G93A Mouse Microglia.Cell Neurosci, 2017 Aug, 11:249. [Content Brief]
Last Update	2025-04-01 14:45:47

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