P7C3-A20 MedChemExpress (MCE)

Product Name	P7C3-A20
Synonyms	CS-2365 P7C3-A20 N-(3-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-2-FLUOROPROPYL)-3-METHOXYANILINE 9H-Carbazole-9-propanamine, 3,6-dibromo-β-fluoro-N-(3-methoxyphenyl)- 3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine Synonyms CS-2365 P7C3-A20 N-(3-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-2-FLUOROPROPYL)-3-METHOXYANILINE 9H-Carbazole-9-propanamine, 3,6-dibromo-β-fluoro-N-(3-methoxyphenyl)- 3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine P7C3-A20 3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine
CAS	1235481-90-9
EINECS
Chemical Formula	C22H19Br2FN2O
Molecular Weight	506.21
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	P7C3-A20 P7C3-A20 MedChemExpress (MCE) HY-15978 1235481-90-9 98.97% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions P7C3-A20 P7C3-A20 MedChemExpress (MCE) HY-15978 1235481-90-9 98.97% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. P7C3-A20 is a derivative of P7C3 with potent proneurogenic and neuroprotective activity. P7C3-A20 exerts an antidepressant-like effect. P7C3-A20 can cross the blood-brain barrier and therefore has the potential for brain injury treatment. P7C3-A20 (10-100 μM 8 hours PC12 cells) treatment alleviates oxygen-glucose deprivation (OGD)-induced cytotoxicity in PC12 cells[1]. P7C3-A20 (40-100 μM 8 hours PC12 cells) treatment alleviates OGD-induced apoptosis in PC12 cells[1]. P7C3-A20 (5-10 mg/kg intraperitoneal injection daily for 7 days Sprague-Dawley rats) treatment reduces infarct volume reverses cell loss in the cortex and hippocampus and improves motor function without causing neurotoxicity in HI model rats. P7C3-A20 prevents HI-induced neuronal injury via activation of the PI3K/AKT/GSK3β signaling pathway[1]. \| \| \| \| \| \| \| \| \| \| [1]. Junjie Bai, et al. The Small Molecule P7C3-A20 Exerts Neuroprotective Effects in a Hypoxic-Ischemic Encephalopathy Model via Activation of PI3K/AKT/GSK3β Signaling. Neuroscience. 2020 Jun 3 S0306-4522(20)30353-5. [Content Brief] [2]. Blaya MO et al. Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury. J Neurotrauma. 2014 Mar 1 31(5):476-86. [Content Brief] [3]. Walker AK et al. The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasinghippocampal neurogenesis. Mol Psychiatry. 2015 Apr 20(4):500-8. [Content Brief]
Last Update	2025-04-01 14:45:47

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