ABBV-075 MedChemExpress (MCE)

Product Name	ABBV-075
Synonyms	5100;ABBV-075;Mivebresib;Mivebresib (ABBV-075 );N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide
CAS	1445993-26-9
EINECS
Chemical Formula	C22H19F2N3O4S
Molecular Weight	459.4658
inchi
Package	10 mM * 1 mL;2 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	Mivebresib Mivebresib MedChemExpress (MCE) HY-100015 1445993-26-9 ABBV-075 99.29% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Mivebresib Mivebresib MedChemExpress (MCE) HY-100015 1445993-26-9 ABBV-075 99.29% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Mivebresib (ABBV-075) is a potent and orally active bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a Ki of 1.5 nM. Mivebresib inhibit DHT-stimulated transcription of AR target genes without significant effect on AR protein expression. In addition to blocking the transcription activation downstream of AR, Mivebresib is also a potent inhibitor of MYC and the TMPRSS2-ETS fusion proteins[1]. IC50: 1.5 nM (BRD4)[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. EJ Faivre et al. Abstract 4694: ABBV-075, a novel BET family inhibitor, disrupts critical transcription programs that drive prostate cancer growth to induce potent anti-tumor activity in vitro and in vivo
Last Update	2025-04-01 14:45:47

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