BEC MedChemExpress (MCE)

Product Name	S-(2-boronoethyl)-L-cysteine hydrochloride
Synonyms	BEC HCl BEC hydrochloride S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE S-(2-boronoethyl)-L-cysteine hydrochloride BEC hydrochloride - S-(2-Boronoethyl)-L-cysteine hydrochloride (R)-2-amino-3-((2-boronoethyl)thio)propanoic acid hydrochloride
CAS	222638-67-7
EINECS
Chemical Formula	C5H13BClNO4S
Molecular Weight	229.48
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	BEC hydrochloride BEC hydrochloride MedChemExpress (MCE) HY-19548A 222638-67-7 98.0% 4°C, stored under nitrogen In solvent : -80°C, 6 months Descriptions BEC hydrochloride BEC hydrochloride MedChemExpress (MCE) HY-19548A 222638-67-7 98.0% 4°C, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (stored under nitrogen) Room temperature in continental US may vary elsewhere. BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively. The X-ray crystal structure of the arginase-BEC complex has been determined at 2.3 Å resolution from crystals perfectly twinned by hemihedry. The structure of the complex reveals that the boronic acid moiety undergoes nucleophilic attack by metal-bridging hydroxide ion to yield a tetrahedral boronate anion that bridges the binuclear manganese cluster, thereby mimicking the tetrahedral intermediate (and its flanking transition states) in the arginine hydrolysis reaction[2]. Administration of the arginase inhibitor BEC decreases arginase activity and causes alterations in NO homeostasis, which are reflected by increases in S-nitrosylated and nitrated proteins in the lungs from inflamed mice. BEC enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and leads to further increases in airways hyperresponsiveness[3]. Ki: 0.31 μM (BEC hydrochloride, at pH 7.5) and 30 nM (BEC hydrochloride, at pH 9.5)[1] In Vitro The X-ray crystal structure of the arginase-BEC complex has been determined at 2.3 Å resolution from crystals perfectly twinned by hemihedry. The structure of the complex reveals that the boronic acid moiety undergoes nucleophilic attack by metal-bridging hydroxide ion to yield a tetrahedral boronate anion that bridges the binuclear manganese cluster, thereby mimicking the tetrahedral intermediate (and its flanking transition states) in the arginine hydrolysis reaction[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BEC hydrochloride Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Colleluori DM, et al. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001 Aug 7 40(31):9356-62. [Content Brief] [2]. Kim NN, et al. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001 Mar 6 40(9):2678-88. [Content Brief] [3]. Ckless K, et al. Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration. J Immunol. 2008 Sep 15 181(6):4255-64. [Content Brief]
Last Update	2025-04-01 14:45:47

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