Necrosulfonamide MedChemExpress (MCE)

Product Name	Necrosulfonamide
Synonyms	100318 CS-2351 Necrosulfonamide (E)-NECROSULFONAMIDE Necrosulfonamide (NSA) (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfaMoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylaMide (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide Synonyms 100318 CS-2351 Necrosulfonamide (E)-NECROSULFONAMIDE Necrosulfonamide (NSA) (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfaMoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylaMide (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide 2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-, (2E)-
CAS	1360614-48-7
EINECS
Chemical Formula	C18H15N5O6S2
Molecular Weight	461.4716
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Necrosulfonamide Necrosulfonamide MedChemExpress (MCE) HY-100573 1360614-48-7 99.47% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Necrosulfonamide Necrosulfonamide MedChemExpress (MCE) HY-100573 1360614-48-7 99.47% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis. Necrosulfonamide specifically blocks necrosis downstream of RIP3 activation. Necrosulfonamide inhibits MLKL-mediated necrosis by blocking Its N-terminal CC domain function[1]. \| \| \| \| \| \| \| \| \| \| [1]. Sun L, et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012 148(1-2):213-227. [Content Brief]
Last Update	2025-04-01 14:45:47

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