ICL 670 MedChemExpress (MCE)

Product Name	Deferasirox
Synonyms	Deferisirox Deferasirox Deferasirox D8 Deferasirox(Exjade) Deferasirox(CGP-72670) 4-[3,5-bis(2-hydroxyphenyl) 4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid Synonyms Deferisirox Deferasirox Deferasirox D8 Deferasirox(Exjade) Deferasirox(CGP-72670) 4-[3,5-bis(2-hydroxyphenyl) 4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid 4-[3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,4-triazolidin-1-yl]benzoic acid 4-[(3Z,5E)-3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,4-triazolidin-1-yl]benzoic acid
CAS	201530-41-8
EINECS	685-491-5
Chemical Formula	C21H15N3O4
Molecular Weight	373.36
inchi	InChI=1/C21H15N3O4/c25-17-7-3-1-5-15(17)19-22-20(16-6-2-4-8-18(16)26)24(23-19)14-11-9-13(10-12-14)21(27)28/h1-12,25-26H,(H,27,28)
Package	10 mM * 1 mL;2 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	Deferasirox Deferasirox MedChemExpress (MCE) HY-17359 201530-41-8 ICL 670 99.65% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Deferasirox Deferasirox MedChemExpress (MCE) HY-17359 201530-41-8 ICL 670 99.65% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload. In LX-2 cells treated with 50 μM deferasirox for 12 h, α1(I)procollagen expression is decreased by 25%, with maximal reductions (10-fold) seen following 24-120 h of treatment. Similarly, α-smooth muscle actin (αSMA) expression is significantly lower[1]. Deferasirox had anti-proliferative effects on HL-60 or KG-1 myeloid leukemia cell lines at a concentration as low as 5 μM . The cytotoxicity is both dose and time dependent[2]. The viability of both EL4 cells and L1210 cells incubated with deferasirox decrease in a concentration-dependent manner[3]. The tumor is significantly smaller in the SIO mice treated with deferasirox compared with control. Mice treated with DFX showed longer survival than the other groups. Deferasirox has a survival benefit for SIO leukemia murine model in terms of iron chelation and antileukemic therapy[3]. Mice: Murine leukemia cells are injected subcutaneously into the right flank of mice. Deferasirox is dissolved in distilled water and orally administered at 20 mg/kg until the cumulative dose reaches 300 mg/kg. The mice are observed and weighed daily[3]. Deferasirox is dissolved in DMSO. HL-60 or KG-1 cells are treated with 0, 5, 10, 50 μM of deferasirox for 24 or 48 h, and proliferation is determined by an MTT assay[2]. \| \| \| \| \| \| \| \| \| \| [1]. Sobbe A, et al. Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox. J Gastroenterol Hepatol. 2015 Mar 30(3):638-45. [Content Brief] [2]. Kim JL, et al. The oral iron chelator deferasirox induces apoptosis in myeloid leukemia cells by targetingcaspase. Acta Haematol. 2011 126(4):241-5. [Content Brief] [3]. Lee DH, et al. Deferasirox shows in vitro and in vivo antileukemic effects on murine leukemic cell lines regardless of iron status. Exp Hematol. 2013 Jun 41(6):539-46. [Content Brief]
Last Update	2025-04-01 14:45:47

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