LY3177833 MedChemExpress (MCE)

Product Name	LY3177833
Synonyms	CS-2783 LY3177833 LY-3177833 LY 3177833 (R)-3-(5-fluoropyrimidin-4-yl)-3-methyl-6-(1H-pyrazol-4-yl)isoindolin-1-one 1H-Isoindol-1-one, 3-(5-fluoro-4-pyrimidinyl)-2,3-dihydro-3-methyl-6-(1H-pyrazol-4-yl)-, (3R)-
CAS	1627696-51-8
EINECS
Chemical Formula	C16H12FN5O
Molecular Weight	309.3
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	LY3177833 LY3177833 MedChemExpress (MCE) HY-100023 1627696-51-8 99.48% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions LY3177833 LY3177833 MedChemExpress (MCE) HY-100023 1627696-51-8 99.48% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. LY3177833 (Example 4) is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively. LY3177833 is a senescence inducer. LY3177833 (10 μM 4 days) increases SA-β-gal content in Hep3B cells[2]. LY3177833 (Example 4 10.4-31.2 mg/kg oral gavage twice a day for 2 weeks female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dose-dependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation[1]. Cdc7 3.3 nM (IC50) pMCM2 290 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Robert Dean Dally, et al. CDC7 Inhibitors. Patent WO2014143601A1. [2]. Li X, et al. First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase. Chem Sci. 2020 Jun 17 11(28):7292-7301. [Content Brief]
Last Update	2025-04-01 14:45:47

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