U-42585E free acid MedChemExpress (MCE)

Product Name	Lodoxamide
Synonyms	Lodoxamide Lodoxamida Lodoxamidum Unii-spu695od73 Lodoxamidum [inn-latin] Lodoxamida [inn-spanish] N,N'-(2-Chlor-5-cyan-3-phenylen)dioxamsaeure Synonyms Lodoxamide Lodoxamida Lodoxamidum Unii-spu695od73 Lodoxamidum [inn-latin] Lodoxamida [inn-spanish] N,N'-(2-Chlor-5-cyan-3-phenylen)dioxamsaeure 2,2'-[(2-Chloro-5-cyano-1,3-phenylene)diimino]bis[2-oxoacetic acid] Acetic acid, 2,2'-((2-chloro-5-cyano-1,3-phenylene)diimino)bis(2-oxo-
CAS	53882-12-5
EINECS
Chemical Formula	C11H6ClN3O6
Molecular Weight	311.63
inchi
Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg;200 mg
Price	Email to quote
Descriptions	Lodoxamide Lodoxamide MedChemExpress (MCE) HY-14270 53882-12-5 U-42585E free acid 98.02% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Lodoxamide Lodoxamide MedChemExpress (MCE) HY-14270 53882-12-5 U-42585E free acid 98.02% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Lodoxamide (U-42585E free acid) is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis. Lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45Ca influx with associated histamine release in purified rat peritoneal mast cells[1]. The chemotactic response of eosinophils to fMLP as well as to IL-5 is significant and dose-dependent inhibited by Lodoxamide. Lodoxamide is also able to strongly inhibit the release of eosinophil peroxidase after IgA-dependent activation and, to a lesser extent, the release of eosinophil cationic protein and eosinophil-derived neurotoxin[2]. Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anesthetized rhesus monkeys[1]. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation, decreased microvascular permeability, and increased compliance[3]. Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty, cough, sputum production, and sleep[4]. \| \| \| \| \| \| \| \| \| \| [1]. Watt GD, et al. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct 66(4):286-94. [Content Brief] [2]. Capron M,et al. Inhibitory effects of lodoxamide on eosinophil activation. Int Arch Allergy Immunol. 1998 Jun 116(2):140-6. [Content Brief] [3]. Barr ML, et al. Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury. J Thorac Cardiovasc Surg. 1998 Mar 115(3):631-6 discussion 636-7. [Content Brief] [4]. Mann JS, et al. Inhaled lodoxamide tromethamine in the treatment of perennial asthma: a double-blind placebo-controlled study. J Allergy Clin Immunol. 1985 Jul 76(1):83-90. [Content Brief]
Last Update	2025-04-01 14:45:47

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