VH032-NH2 monohydrochloride; VHL ligand 1 monohydrochloride MedChemExpress (MCE)

Product Name	(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Synonyms	ULM-1 MDK-7526 Protein degrader 1 (S,R,S)-AHPC hydrochloride (4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide hydrochloride (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
CAS	1448189-80-7
EINECS	604-604-1
Chemical Formula	C22H31ClN4O3S
Molecular Weight	467.02454
inchi
Package	100 mg;500 mg;1 g
Price	Email to quote
Descriptions	(S,R,S)-AHPC monohydrochloride (S,R,S)-AHPC monohydrochloride MedChemExpress (MCE) HY-101763A 1448189-80-7 VH032-NH2 monohydrochloride Descriptions (S,R,S)-AHPC monohydrochloride (S,R,S)-AHPC monohydrochloride MedChemExpress (MCE) HY-101763A 1448189-80-7 VH032-NH2 monohydrochloride VHL ligand 1 monohydrochloride 99.83% -20°C, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (stored under nitrogen) Room temperature in continental US may vary elsewhere. (S,R,S)-AHPC (VH032-NH2 VHL ligand 1) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein[1]. VHL \| \| \| \| \| \| \| \| \| \| [1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.ACS Chem Biol. 2015 Aug 21 10(8):1831-7. [Content Brief]* [2]. Krieger J, et al. Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design. ChemMedChem. 2023 Apr 17 18(8):e202200615. [Content Brief] [3]. Vu LP, et al. Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers[J]. J Med Chem. 2023 Sep 28 66(18):12776-12811. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Protein_degrader_1_hydrochloride.html
Last Update	2025-05-21 16:50:25

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