(1S,3R)-RSL3 MedChemExpress (MCE)

Product Name	RSL3
Synonyms	RSL3 CS-2409 methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methoxycarbonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate (1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate
CAS	1219810-16-8
EINECS
Chemical Formula	C23H21ClN2O5
Molecular Weight	440.88
inchi
Package	10 mM * 1 mL;2 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	RSL3 RSL3 MedChemExpress (MCE) HY-100218A 1219810-16-8 (1S,3R)-RSL3 99.90% 4°C, sealed storage, away from moisture In solvent : -80°C, 2 years Descriptions RSL3 RSL3 MedChemExpress (MCE) HY-100218A 1219810-16-8 (1S,3R)-RSL3 99.90% 4°C, sealed storage, away from moisture In solvent : -80°C, 2 years -20°C, 1 year (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells. RSL3 (0-8 μM, 72 hours) potently reduces the viability of HN3 cells, with IC50s of 0.48 μM in HN3 and 5.8 μM in HN3-rslR cells, respectively[1]. RSL3 (0-8 μM, 24 hours) reduces the expression of GPX4 protein, increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells[1]. Ferroptosis-sensitive Cell Lines Ferroptosis-sensitive Cells Test Conditions MCF10A-RAS[2] 0-10 μM 48 h MDA-MB-468[3] 0.1-1 μM 24 h PC-3[3] 0.01-1 μM 24 h Huh-7[3] 0.01-1 μM 24 h Raji[3] 0.01-1 μM 24 h MEF[3] 0.1-100 nM 24 h HT-22 neuron[4] 200 nM 16 h NCI-H508[5] 0.1-10 μM 48 h LoVo[5] 0.1-10 μM 48 h LS513[5] 0.1-10 μM 48 h SW480[5] 0.1-10 μM 48 h SW620[5] 0.1-10 μM 48 h SW1116[5] 0.1-10 μM 48 h DLD-1[5] 0.1-10 μM 48 h Caco-2[5] 0.1-10 μM 48 h HT-1080[6] 0-10 μM 48 h IC50 1.55 μM MDA-MB-436[7] 0.1-2 μM 24 h HT-29[7] 0.1-2 μM 24 h U-373[7] 0.1-2 μM 24 h A549[8] 1 nM-100 μM 24 h IC50 0.5 μM H1975[8] 1 nM-100 μM 24 h IC50 150 nM MAD-MB-231[9] 0-10 μM 96 h IC50 0.71 μM HCC1937[9] 0-10 μM 96 h IC50 0.85 μM Ferroptosis-insensitive Cell Lines Ferroptosis-insensitive Cells Test Conditions HS578T[10] 0-2.5 μM 24 h MCF10A[10] 0-2.5 μM 24 h RSL3 (100 mg/kg, Intratumorally twice per week for 20 days) significantly inhibits the growth of tumor in combination with Trigonelline (HY-N0414) in mice bearing HN3R cells[1]. Glutathione peroxidase 4[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Shin D, et al. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018 Dec 129:454-462. [Content Brief] [2]. Romani P, et al., Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance. Nat Cell Biol. 2022 Feb 24(2):168-180. [Content Brief] [3]. Zhang Z, et al., CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes. Nat Chem Biol. 2024 Jan 11. [Content Brief] [4]. Chen T, et al., Mitochondrial transplantation rescues neuronal cells from ferroptosis. Free Radic Biol Med. 2023 Nov 1 208:62-72. [Content Brief] [5]. Zhu JF, et al., Ibrutinib facilitates the sensitivity of colorectal cancer cells to ferroptosis through BTK/NRF2 pathway. Cell Death Dis. 2023 Feb 23 14(2):151. [Content Brief] [6]. Song H, et al., A potent GPX4 degrader to induce ferroptosis in HT1080 cells. Eur J Med Chem. 2024 Feb 5 265:116110. [Content Brief] [7]. Zheng J, et al., Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines. Cell Death Dis. 2021 Jul 13 12(7):698. [Content Brief] [8]. Cheff DM, et al., The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1. Redox Biol. 2023 Jun 62:102703. [Content Brief] [9]. Li P, et al., Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death Dis. 2022 Sep 21 13(9):808. [Content Brief] [10]. Brown CW, et al., Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export. Dev Cell. 2019 Dec 2 51(5):575-586.e4. [Content Brief]
Last Update	2025-04-01 14:45:47

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