FG9065 MedChemExpress (MCE)

Product Name	6-Cyano-7-Nitroquinoxaline-2,3-Dione
Synonyms	CNQX;FG-9065;CNQX 2NA;CNQX DISODIUM;CNQX DISODIUM SALT;6-Cyano-7-Nitroquinoxaline-2,3-Dione;6-CYANO-7-NITROQUINOXALINE-2,3 (1H,4H)-DIONE;7-Nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile
CAS	115066-14-3
EINECS
Chemical Formula	C9H4N4O4
Molecular Weight	232.15
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	CNQX CNQX MedChemExpress (MCE) HY-15066 115066-14-3 FG9065 99.38% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions CNQX CNQX MedChemExpress (MCE) HY-15066 115066-14-3 FG9065 99.38% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist. CNQX blocks the expression of fear-potentiated startle in rats. CNQX (FG9065 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2]. CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3]. CNQX (FG9065 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2]. CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3]. Kainate Receptor \| \| \| \| \| \| \| \| \| \| [1]. T Honoré, et al. Quinoxalinediones: Potent Competitive non-NMDA Glutamate Receptor Antagonists. Science. 1988 Aug 5 241(4866):701-3. [Content Brief] [2]. Neuman RS, et al. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione(CNQX) in the hippocampus in vitro. Neurosci Lett. 1988 Sep 23 92(1):64-8. [Content Brief] [3]. Alford S, et al. CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. Brain Res. 1990 Jan 8 506(2):297-302. [Content Brief] [4]. Pia Bäckström, et al. Attenuation of Cocaine-Seeking Behaviour by the AMPA/kainate Receptor Antagonist CNQX in Rats. Psychopharmacology (Berl). 2003 Feb 166(1):69-76. [Content Brief] [5]. Kim M, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol. 1993 Jan 59(1):5-8. [Content Brief]
Last Update	2025-04-01 14:45:47

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