Cereblon ligand 3; E3 ligase Ligand 3 MedChemExpress (MCE)

Product Name	2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid
Synonyms	TC E3 5031 Thalidomide-Acid Cereblon ligand 3 Cereblon Ligand 1 Thalidomide-O-COOH Pomalidomide Related Compound 1 2-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1,3-DIOXOISOINDOLIN-4-YL]OXY]ACETIC ACID Synonyms TC E3 5031 Thalidomide-Acid Cereblon ligand 3 Cereblon Ligand 1 Thalidomide-O-COOH Pomalidomide Related Compound 1 2-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1,3-DIOXOISOINDOLIN-4-YL]OXY]ACETIC ACID 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid 2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid
CAS	1061605-21-7
EINECS
Chemical Formula	C15H12N2O7
Molecular Weight	332.27
inchi
Package	100 mg;250 mg;1 g;5 g;10 g
Price	Email to quote
Descriptions	Thalidomide-O-COOH Thalidomide-O-COOH MedChemExpress (MCE) HY-103597 1061605-21-7 Cereblon ligand 3 Descriptions Thalidomide-O-COOH Thalidomide-O-COOH MedChemExpress (MCE) HY-103597 1061605-21-7 Cereblon ligand 3 E3 ligase Ligand 3 99.85% 4°C, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (stored under nitrogen) Room temperature in continental US may vary elsewhere. Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs. Cereblon \| \| \| \| \| \| \| \| \| \| [1]. Bozilovic J, et al. Novel, highly potent PROTACs targeting AURORA-A kinase. Current Research in Chemical Biology. 2022, 2: 100032. [2]. Yamanaka S, et al. Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation. Nat Commun. 2023 Aug 18 14(1):4683. [Content Brief]*
Last Update	2025-04-01 14:45:47

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