LDN-192960 MedChemExpress (MCE)

Product Name	3-(2,7-dimethoxyacridin-9-ylthio)propan-1-amine
Synonyms	CS-613 LDN-192960 LDN-192960 2HCl LDN-192960 dihydrochloride 2,7-Dimethoxy-9-(3'-aminopropyl)thioacridine 3-(2,7-dimethoxyacridin-9-ylthio)propan-1-amine 1-Propanamine, 3-[(2,7-dimethoxy-9-acridinyl)thio]- Synonyms CS-613 LDN-192960 LDN-192960 2HCl LDN-192960 dihydrochloride 2,7-Dimethoxy-9-(3'-aminopropyl)thioacridine 3-(2,7-dimethoxyacridin-9-ylthio)propan-1-amine 1-Propanamine, 3-[(2,7-dimethoxy-9-acridinyl)thio]- LDN-192960 3-(2,7-diMethoxyacridin-9-ylthio)propan-1-aMine 3-[(2,7-Dimethoxy-9-acridinyl)thio]-1-propanamine dihydrochloride 3-[(2,7-Dimethoxyacridin-9-yl)thio]propan-1-amine dihydrochloride
CAS	184582-62-5
EINECS
Chemical Formula	C18H20N2O2S
Molecular Weight	328.43
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	LDN-192960 LDN-192960 MedChemExpress (MCE) HY-13455 184582-62-5 98.04% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions LDN-192960 LDN-192960 MedChemExpress (MCE) HY-13455 184582-62-5 98.04% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. LDN-192960 is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively. LDN-192960 (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC5050=0.21 μM), DYRK1A (IC50= 0.10 μM), DYRK2 (IC50=2 nM), DYRK3 (IC50=19 nM) and PIM1 (IC50=0.72 μM)[1].LDN-0192960 (0-5 μM 2 hours) demonstrates that the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells overexpressing Haspin with an EC50 of 1.17 μM[2].LDN-0192960 (0-1 μM 1 hour incubation in the presence of nocodazole and MG132) demonstrates the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells synchronized in mitosis with an EC50 of 0.02 μM[2]. DYRK1 DYRK2 \| \| \| \| \| \| \| \| \| \| [1]. Cuny GD, et al. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15 20(12):3491-4. [Content Brief] [2]. Katrin Kestav, et al. Structure, Roles and Inhibitors of a Mitotic Protein Kinase Haspin. Curr Med Chem. 2017 24(21):2276-2293. [Content Brief]
Last Update	2025-04-01 14:45:47

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