Tyrphostin AG126 MedChemExpress (MCE)

Product Name	TYRPHOSTIN AG 126
Synonyms	ag127;AG 126;TYRPHOSTIN A10;Tyrphostin 126;TYRPHOSTIN AG 126;RARECHEM AL BX 0673;[3-HYDROXY-4-NITROBENZYLIDENE]MALONONITRILE;ALPHA-CYANO-(3-HYDROXY-4-NITRO)CINNAMONITRILE
CAS	118409-62-4
EINECS
Chemical Formula	C10H5N3O3
Molecular Weight	215.16
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	AG126 AG126 MedChemExpress (MCE) HY-108330 118409-62-4 Tyrphostin AG126 98.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions AG126 AG126 MedChemExpress (MCE) HY-108330 118409-62-4 Tyrphostin AG126 98.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research. AG126 (10 μM overnight) increases the viability of ARPE-19 cells[2]. AG126 at concentrations higher than 10 μM show toxic to ARPE-19 cells and can enhance H2O2 toxicity[2]. AG126 (0.1-100 μM) inhibits VEGF-induced proliferation of BRMECs[4]. AG 126 (intraperitoneal injection 1-10 mg/kg 1 h and 6 h after Zymosan treatment) treatment attenuates the degree of multiple organ failure (MOF) associated with Zymosan-induced peritonitis in the rat[3]. ERK2 \| \| \| \| \| \| \| \| \| \| [1]. Cuzzocrea S, et al. The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation. Am J Pathol. 2000 Jul 157(1):145-58. [Content Brief] [2]. Garg TK, et al. Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. BMC Ophthalmol. 2003 Mar 21 3:5. [Content Brief] [3]. Dugo L, et al. The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat. Intensive Care Med. 2002 Jun 28(6):775-88. [Content Brief] [4]. Bullard LE, et al. Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis. Invest Ophthalmol Vis Sci. 2003 Apr 44(4):1722-31. [Content Brief]
Supplier Website	https://www.medchemexpress.com/AG126.html
Last Update	2025-05-21 16:50:25

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