Robenidine MedChemExpress (MCE)

Product Name	Robenidine HCL
Synonyms	Robenidine HCL Robenidine hyd Robenidine HCL Pure Robenidine Hydrochoride Robenidine hydrochloride KhiMcoccid Hydrochloride ChiMcoccid Hydrochloride Synonyms Robenidine HCL Robenidine hyd Robenidine HCL Pure Robenidine Hydrochoride Robenidine hydrochloride KhiMcoccid Hydrochloride ChiMcoccid Hydrochloride 1,3-Bis(4-chlorobenzylideneaMino)guanidine Hydrochloride Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride 2,2'-Bis[(4-chlorophenyl)Methylene]carboniMidic Dihydrazide Hydrochloride (1E)-2-{(E)-amino[(2E)-(4-chlorobenzylidene)hydrazinylidene]methyl}-1-(4-chlorobenzylidene)hydrazinium chloride
CAS	25875-50-7
EINECS	247-307-8
Chemical Formula	C15H14Cl3N5
Molecular Weight	370.66
inchi	InChI=1/C15H13Cl2N5.ClH/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12;/h1-10H,(H3,18,21,22);1H/b19-9+,20-10+
Package	10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Robenidine hydrochloride Robenidine hydrochloride MedChemExpress (MCE) HY-B2157 25875-50-7 98.0% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Robenidine hydrochloride Robenidine hydrochloride MedChemExpress (MCE) HY-B2157 25875-50-7 98.0% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively. Robenidine (compound 1) inhibits the growth of MRSA and VRE with MIC values of 8.1 and 4.7 μM, respectively. Robenidine is bactericidal against all of the S. aureus strains tested with MBC/MIC90 ratios ≤2. A profound and negative impact on the MIC values with a 4-fold decrease with Robenidine at 2% serum and no activity at 50% serum is observed[1]. The time that the mean plasma concentration exceeds the concentration of 1 μg/mL is approximately 6 h in the Florfenicol (FFC) alone group however, it is lowered to 4 h by Robenidine (ROB) pretreatment. The terminal elimination half-life (t1/2z), area under the concentration-time curve (AUC), area under the first moment curve (AUMC), and mean residence time (MRT) significantly decreased, whereas the elimination rate constant (λz) and total body clearance (CLz) obviously increased in rabbits pretreated with Robenidine[2]. The rabbits are divided into four groups (n=8, each group). The rabbits in the control group are fed anticoccidial-free rations throughout the study. Rabbits in the other group are fed rations containing Robenidine (ROB) (66 ppm) for 20 consecutive days. At the end of the 20th day of feeding, a single dose of Florfenicol (FFC) is injected intravenously at 25 mg/kg body weight (b.w.) into the left auricular vein of each rabbit in all groups. Blood (approximately 1 mL) samples are collected into heparin-coated tubes from the right auricular vein of each rabbit at 5, 10, 15, 30, and 45 min and 1, 1.5, 2, 4, 6, 8, and 12 h after administration of FFC. The plasma is harvested after centrifugation at 3,000 g for 10 min and stored at -20°C until analysis[2]. MRSA clinical isolates are used in this study and the MIC50 for Robenidine (compound 1) is determined using a modified MIC assay. The antimicrobial dilutions of Robenidine are completed in 100% DMSO, with 2 μL added to each well. The assay is performed in a total volume of 200 μL in 96-well plates. Robenidine is tested in final concentrations of 0.7 to 345.3 μM. Plates are incubated for 20 to 24 h at 37°C before determination of the MIC[1]. Coccidia \| \| \| \| \| \| \| \| \| \| [1]. Abraham RJ, et al. Robenidine Analogues as Gram-Positive Antibacterial Agents. J Med Chem. 2016 Mar 10 59(5):2126-38. [Content Brief] [2]. Liu C, et al. Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits. Exp Anim. 2015 64(1):73-9. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Robenidine_hydrochloride.html
Last Update	2025-05-21 16:50:25

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