Abequolixron hydrochloride MedChemExpress (MCE)

Product Name	RGX-104
Synonyms	RGX104;CPD1632;RGX 104;CS-2843;RGX-104;RGX-104 (HCl);RGX-104 hydrochloride;2-[3-[(3R)-3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]butoxy]phenyl]acetic acid
CAS	610318-03-1
EINECS
Chemical Formula	C34H34Cl2F3NO3
Molecular Weight	632.55
inchi
Package	10 mM * 1 mL;2 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	RGX-104 hydrochloride RGX-104 hydrochloride MedChemExpress (MCE) HY-111498 610318-03-1 Abequolixron hydrochloride 99.88% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions RGX-104 hydrochloride RGX-104 hydrochloride MedChemExpress (MCE) HY-111498 610318-03-1 Abequolixron hydrochloride 99.88% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. RGX-104 hydrochloride is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene. Oral administration of GW3965 or RGX-104 hydrochloride to animals bearing palpable tumors significantly suppresses the growth of multiple cancer types. Strong tumor growth suppression is also observed in animals bearing large tumors. In some instances, the treatment causes partial or complete tumor regression. Responses are seen across a wide spectrum of malignancies, including lung cancer, melanoma, glioblastoma, and ovarian, renal cell, triple-negative breast, and colon cancer[1]. Mice[1] B16F10 cancer cells are subcutaneously injected into C57BL/6 mice. Following tumor growth to 5-10 mm3 in volume, mice are fed either control chow, chow supplemented with GW3965 (100 mg/kg), or chow supplemented with RGX-104 (100 mg/kg)[1]. Bone marrow cells are cultured with B16F10 melanoma cells and GM-CSF for 6 days. On day 3, RGX-104 (2 μM) is added to the culture. The mean number of Gr-1high CD11b+ cells per 50 mL of culture solution is assessed by flow cytometry on day 6[1]. LXR[1] In Vivo Oral administration of GW3965 or RGX-104 hydrochloride to animals bearing palpable tumors significantly suppresses the growth of multiple cancer types. Strong tumor growth suppression is also observed in animals bearing large tumors. In some instances, the treatment causes partial or complete tumor regression. Responses are seen across a wide spectrum of malignancies, including lung cancer, melanoma, glioblastoma, and ovarian, renal cell, triple-negative breast, and colon cancer[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. \| \| \| \| \| \| \| \| \| \| [1]. Tavazoie MF, et al. LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer. Cell. 2018 Feb 8 172(4):825-840.e18. [Content Brief]
Last Update	2025-04-01 14:45:47

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