Flupenthixol dihydrochloride MedChemExpress (MCE)

Product Name	Fupentixol Dihydrochloride
Synonyms	fx703 flupentixolhydrochloride Flupentixol Hydrochloride FUPENTIXOL DIHYDROCHLORIDE Fupentixol Dihydrochloride FLUPENTIXOL DIHYDROCHLORIDE (CIS+TRANS) 4-(3-(2-trifluoromethylthioxanth-9-ylidene)propyl)-1-piperazineethanodih Synonyms fx703 flupentixolhydrochloride Flupentixol Hydrochloride FUPENTIXOL DIHYDROCHLORIDE Fupentixol Dihydrochloride FLUPENTIXOL DIHYDROCHLORIDE (CIS+TRANS) 4-(3-(2-trifluoromethylthioxanth-9-ylidene)propyl)-1-piperazineethanodih 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl)-1-piperazineethanold thioxanthene,9-(3-(4-(2-hydroxyethyl)piperazinyl)propylidene)-2-trifluoromethy (4-[3-[2-TRIFLUOROMETHYL)-9H-THIOXANTHEN-9-YLIDENE]PROPYL]-1-PIPERAZINEETHANOL 2HCL 2-(4-{(3E)-3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethanol 4-[3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]piperazine-1-ethanol dihydrochloride (Z)-4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]piperazine-1-ethanol dihydrochloride 2-(4-{3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethanol dihydrochloride 2-(4-{(3Z)-3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethanol dihydrochloride 2-[4-[3-[(EZ)-2-(TRIFLUOROMETHYL)-9H-THIOXANTHEN-9-YLIDENE]PROPYL] PIPERAZIN-1-YL]ETHANOL DIHYDROCHLORIDE
CAS	2413-38-9
EINECS	219-321-4
Chemical Formula	C23H25F3N2OS.2ClH
Molecular Weight	507.44
inchi	InChI=1/C23H25F3N2OS.2ClH/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29;;/h1-2,4-8,16,29H,3,9-15H2;2*1H/b18-5-;
Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Flupentixol dihydrochloride Flupentixol dihydrochloride MedChemExpress (MCE) HY-15856B 2413-38-9 Flupenthixol dihydrochloride 98.52% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months Descriptions Flupentixol dihydrochloride Flupentixol dihydrochloride MedChemExpress (MCE) HY-15856B 2413-38-9 Flupenthixol dihydrochloride 98.52% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Flupentixol is an orally active D1/D2 dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC50=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research. Flupentixol (2.5-40 μM 72 h) treatment inhibits the viability of lung cancer cells in a dose-dependent manner[3]. Flupentixol (2.5-40 μM 24 h) induces apoptosis in lung cancer cells[3]. Flupentixol (2.5-15 μM 24 h) inhibits p-AKT and Bcl-2 expression levels[3]. Flupentixol (intragastric injection 40 mg/kg once daily 21 d) suppresses A549 xenografted tumor growth in nude mice[3]. PI3Kα 127 nM (IC50) D1 Receptor D2 Receptor \| \| \| \| \| \| \| \| \| \| [1]. Yonar D, et al. Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol. Chem Phys Lipids. 2016 Jun 198:61-71. [Content Brief] [2]. Ruhrmann S, et al. Efficacy of flupentixol and risperidone in chronic schizophrenia with predominantly negative symptoms. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30 31(5):1012-22. [Content Brief] [3]. Chao Dong, et al. The antipsychotic agent flupentixol is a new PI3K inhibitor and potential anticancer drug for lung cancer. Int J Biol Sci. 2019 Jun 2 15(7):1523-1532. [Content Brief]
Last Update	2025-04-01 14:45:47

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