ME0328 MedChemExpress (MCE)

Product Name	ME0328
Synonyms	ME0328 ME 0328 ME-0328 4-Dihydro-4-oxo-3 4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide (S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide 2-Quinazolinepropanamide, 3,4-dihydro-4-oxo-N-[(1S)-1-phenylethyl]- Synonyms ME0328 ME 0328 ME-0328 4-Dihydro-4-oxo-3 4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide (S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide 2-Quinazolinepropanamide, 3,4-dihydro-4-oxo-N-[(1S)-1-phenylethyl]- 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
CAS	1445251-22-8
EINECS	808-923-8
Chemical Formula	C19H19N3O2
Molecular Weight	321.37
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	ME0328 ME0328 MedChemExpress (MCE) HY-100225 1445251-22-8 99.64% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions ME0328 ME0328 MedChemExpress (MCE) HY-100225 1445251-22-8 99.64% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. ME0328 is a potent and selective ARTD3/PARP3 inhibitor with an IC50 of 0.89±0.28 μM. ME0328 is a potent and selective inhibitor of ARTD3/PARP3 that is active in cells. In in vitro histone H1 modification assay, ME0328 inhibits the transferase activity of ARTD3 with an IC50 of 0.89±0.28 μM. In human A549 cells, ME0328 and ME0355 (at 10 μM) delay the resolution of γH2AX-containing foci that serve as markers for DNA double strand break repair following γ-irradiation (2 Gy). In silico and in vitro physicochemical and metabolic profiling indicated that ME0328 is soluble, cell permeable, and metabolically stable in human liver microsomes and rat hepatocytes[1]. ARTD3/PARP3 0.89 μM (IC50) ARTD1/PARP1 6.3 μM (IC50) ARTD2/PARP2 10.8 μM (IC50) ARTD6/TNKS2 34.3 μM (IC50) ARTD5/TNKS1 47.3 μM (IC50) ARTD10/PARP10 71.3 μM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Lindgren AE, et al. PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem Biol. 2013 Aug 16 8(8):1698-703. [Content Brief]
Supplier Website	https://www.medchemexpress.com/ME0328.html
Last Update	2025-05-21 16:50:25

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