Phenprocoumon MedChemExpress (MCE)

Product Name	Phenprocoumon
Synonyms	PHENPROCOUMON Phenprocoumon 3-(1'-Phenyl-propyl)-4-oxycoumarin 3-(1-Phenylpropyl)-4-hydroxycoumarin 3-(alpha-Ethylbenzyl)-4-hydroxycoumarin Coumarin, 3-(alpha-ethylbenzyl)-4-hydroxy- 4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one Synonyms PHENPROCOUMON Phenprocoumon 3-(1'-Phenyl-propyl)-4-oxycoumarin 3-(1-Phenylpropyl)-4-hydroxycoumarin 3-(alpha-Ethylbenzyl)-4-hydroxycoumarin Coumarin, 3-(alpha-ethylbenzyl)-4-hydroxy- 4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one 4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one 2H-1-Benzopyran-2-one, 4-hydroxy-3-(1-phenylpropyl)-
CAS	435-97-2
EINECS	207-108-9
Chemical Formula	C18H16O3
Molecular Weight	280.32
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Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Phenprocoumon Phenprocoumon MedChemExpress (MCE) HY-A0145 435-97-2 98.02% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Phenprocoumon Phenprocoumon MedChemExpress (MCE) HY-A0145 435-97-2 98.02% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K. After a single i.v.-dose of phenprocoumon (0.355 mg/kg) the anticoagulant effect obtained is greater in older than in younger rats. There are no differences between younger and older rats in the rate of elimination, volume of distribution and in the free fraction and free concentration values of phenprocoumon in plasma and liver. After i.v.-injection of 64.3 μg/kg [3H]vitamin K1 and different doses of phenprocoumon (0.02 to 3 mg/kg) the [3H]vitamin K1 concentration in the liver decreases and the [3H] vitamin K1-2, 3-epoxide concentration increases dependent on the dose and the liver concentration of phenprocoumon. These changes are more pronounced in the older than in the younger rats[2]. Vitamin K[1]. In Vivo After a single i.v.-dose of phenprocoumon (0.355 mg/kg) the anticoagulant effect obtained is greater in older than in younger rats. There are no differences between younger and older rats in the rate of elimination, volume of distribution and in the free fraction and free concentration values of phenprocoumon in plasma and liver. After i.v.-injection of 64.3 μg/kg [3H]vitamin K1 and different doses of phenprocoumon (0.02 to 3 mg/kg) the [3H]vitamin K1 concentration in the liver decreases and the [3H] vitamin K1-2, 3-epoxide concentration increases dependent on the dose and the liver concentration of phenprocoumon. These changes are more pronounced in the older than in the younger rats[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. \| \| \| \| \| \| \| \| \| \| [1]. Straubhaar B, et al. The prevalence of potential drug-drug interactions in patients with heart failure at hospital discharge. Drug Saf. 2006 29(1):79-90. [Content Brief] [2]. DIETMAR TRENK, et al. Age-dependent differences in the effect of phenprocoumon on the vitamin K1-epoxide cycle in rats. Trenk D. J Pharm Pharmacol. 1980 Dec 32(12):828-32. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Phenprocoumon.html
Last Update	2025-05-21 16:50:25

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