JNJ 28431754 hemihydrate MedChemExpress (MCE)

Product Name	canagliflozin
Synonyms	Cageline canagliflozin Cagliflozin heMihydrate Canagliflozin heMihydrate Canagliflozin heMihydrates 1-(β-D-glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienyl-methyl) benzene (1s)-1,5-anhydro-1-c-(3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4-methylphenyl)-d-glucitol Synonyms Cageline canagliflozin Cagliflozin heMihydrate Canagliflozin heMihydrate Canagliflozin heMihydrates 1-(β-D-glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienyl-methyl) benzene (1s)-1,5-anhydro-1-c-(3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4-methylphenyl)-d-glucitol (2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Hemihydrate
CAS	842133-18-0;928672-86-0
EINECS	202-303-5
Chemical Formula	2(C24H25FO5S).H2O
Molecular Weight	462.53
inchi
Package	10 mM * 1 mL;100 mg;500 mg;1 g
Price	Email to quote
Descriptions	Canagliflozin hemihydrate Canagliflozin hemihydrate MedChemExpress (MCE) HY-I0383 928672-86-0 JNJ 28431754 hemihydrate 99.95% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Canagliflozin hemihydrate Canagliflozin hemihydrate MedChemExpress (MCE) HY-I0383 928672-86-0 JNJ 28431754 hemihydrate 99.95% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Canagliflozin hemihydrate (JNJ28431754 hemihydrate) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively. Canagliflozin inhibits Na+-dependent 14C-AMG uptake in CHO-hSGLT2 cells, with an IC50 of 4.4±1.2 nM. Similar IC50 values are obtained in CHO-rSGLT2 and CHO-mSGLT2 cells (IC50 = 3.7 and 2.0 nM for rat and mouse SGLT2, respectively). Canagliflozin inhibits 14C-AMG uptake in CHO-hSGLT1 and mSGLT1 cells with IC50 of 684±159 nM and >1,000 nM, respectively[1]. Canagliflozin (30 mg/kg treatment for 4 weeks) reduces blood glucose (BG) levels, respiratory exchange ratio, and body weight gain in DIO mice[1]. Canagliflozin (3 mg/kg for 3 weeks) increases urinary glucose excretion (UGE) with no significant change in total food intake compared with that in vehicle-treated rats, leading to a decrease in body weight In ZF rats[1]. SGLT2 \| \| \| \| \| \| \| \| \| \| [1]. Liang Y, et al. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS One. 2012 7(2):e30555. [Content Brief]
Last Update	2025-04-01 14:45:47

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