BML-210 MedChemExpress (MCE)

Product Name	BML-210
Synonyms	CS-2301;BML-210;CAY10433;BML-210, (BML210;BML-210(CAY10433);N-(2-AMINOPHENYL)-N'-PHENYL-OCTANEDIAMIDE;N1-(2-aminophenyl)-N8-phenyl-octanediamide;N-PHENYL-N'-(2-AMINOPHENYL)HEXAMETHYLENEDIAMIDE
CAS	537034-17-6
EINECS
Chemical Formula	C20H25N3O2
Molecular Weight	339.43
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	BML-210 BML-210 MedChemExpress (MCE) HY-19350 537034-17-6 98.06% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions BML-210 BML-210 MedChemExpress (MCE) HY-19350 537034-17-6 98.06% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. BML-210 is a potent HDAC inhibitor. BML-210 can inhibit the HDAC4-VP16-driven reporter signal with an apparent IC50 of ∼5 µM. BML-210 has a specific disruptive effect on the HDAC4:MEF2 interaction. BML-210 causes an increase in the G0/G1 phase. BML-210 induces apoptosis and displays antitumour activities in orthotopic mammary tumours in mice. BML-210 (10, 20 μM 24, 48 hours) inhibits cell proliferation and growth inhibition of NB4 cells[2]. BML-210 (10, 20 μM 24, 48 hours) causes a decrease in the proportion of NB4 cells in the S phase and an increase in the G0/G1 phase[2]. BML-210 (10, 20 μM 24, 48 hours) causes cytotoxic effects on NB4 cells at 20 μM. BML-210 at a dose of 10 μM induces apoptotic cell death[2]. BML-210 (10, 20 μM 24, 48 hours) inhibits HDAC Expression and Activity in NB4 Cells[2]. BML-210 (1.0 μM for 48 h) causes higher expression levels differential expressed genes (DEGs) in mouse EO771 cells[3]. BML-210 does not reduce the expression of HDAC4-VP16[1]. BML-210 (20 mg/kg IP three times per week for two weeks) notably suppresses the tumour growth and weight. BML-210 has no effect on tumour growth and weight in the immune-deficient nude (Nu/J) mice[3]. HDAC4:MEF2 \| \| \| \| \| \| \| \| \| \| [1]. Nimanthi Jayathilaka, et al. Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2. Nucleic Acids Res. 2012 Jul 40(12): 5378–5388. [2]. Veronika Borutinskaite, et al. The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming. Int J Mol Sci. 2015 Aug 16(8): 18252–18269. [3]. Zhuolong Zhou, et al. An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity. Nat Biomed Eng. 2021 Nov 5(11):1320-1335. [Content Brief]
Last Update	2025-04-01 14:45:47

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