Sch 1000 bromide hydrate MedChemExpress (MCE)

Product Name	Ipratropium bromide hydrate
Synonyms	Unii-J697uz2A9j pratropium Bromide IPRATROPIUM BROMIDE Ipratropium bromide CRS Ipratropium bromide hydrate Ipratropium Bromide (100 mg) Ipratropium bromide monohydrate Synonyms Unii-J697uz2A9j pratropium Bromide IPRATROPIUM BROMIDE Ipratropium bromide CRS Ipratropium bromide hydrate Ipratropium Bromide (100 mg) Ipratropium bromide monohydrate IPRATROPIUM BROMIDE MONOHYDRATE 8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl 3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane bromide monohydrate
CAS	66985-17-9
EINECS	622-130-2
Chemical Formula	C20H32BrNO4
Molecular Weight	430.38
inchi	InChI=1/C20H30NO3.BrH.H2O/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;;/h4-8,14,16-19,22H,9-13H2,1-3H3;1H;1H2/q+1;;/p-1
Package	10 mM * 1 mL;10 mg;25 mg;50 mg;100 mg;200 mg;500 mg
Price	Email to quote
Descriptions	Ipratropium bromide hydrate Ipratropium bromide hydrate MedChemExpress (MCE) HY-B1332 66985-17-9 Sch 1000 bromide hydrate 99.90% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Ipratropium bromide hydrate Ipratropium bromide hydrate MedChemExpress (MCE) HY-B1332 66985-17-9 Sch 1000 bromide hydrate 99.90% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Ipratropium bromide (Sch 1000) hydrate is a muscarinic receptor antagonist, with IC50s of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide hydrate relaxes smooth muscle, can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma. Ipratropium bromide hydrate (1 nM, 10 nM, 100 nM 15 min) exerts its toxic effects via disruption of mitochondrial membrane potential[1]. Ipratropium bromide hydrate (1 nM-1 μM 4 h) increases infarct size in isolated perfused heart ischaemia/reperfusion experiments with a dose-responsive manner (EC50=22.7 nM)[1]. Ipratropium bromide hydrate (0.001 nM-0.1 mM 2 h) inhibits adult rat cardiac myocyte growth after 4 h hypoxia treatment[1]. Ipratropium bromide hydrate (1.0 μg/kg i.v. single dose) enhances vagal nerve stimulation induing bronchoconstriction[2]. Ipratropium bromide hydrate (0.04 mg/20 mL and 0.20 mg/20 mL inhalation for 30 min, rate=30 mL/30 min) can protect the lungs against the cadmium-induced acute neutrophilic inflammation by reducing the parenchyma inflammatory infiltration of neutrophils[4]. mAChR1 2.9 nM (IC50) mAChR2 2 nM (IC50) mAChR3 1.7 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Fryer AD, et al. Maclagan, Ipratropium bromide potentiates bronchoconstriction induced by vagal nerve stimulation in the guinea-pig. Eur J Pharmacol, 1987. 139(2): p. 187-91. [Content Brief] [2]. Harvey, et al. Maddock, Ipratropium Bromide-Mediated Myocardial Injury in In Vitro Models of Myocardial Ischaemia/Reperfusion. Toxicol Sci, 2014. [Content Brief] [3]. Maria Prat, et al. Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonists. Bioorg Med Chem Lett. 2015 Apr 15 25(8):1736-1741. [Content Brief] [4]. Wenhui Zhang, et al. Anti-inflammatory effects of formoterol and ipratropium bromide against acute cadmium-induced pulmonary inflammation in rats. Eur J Pharmacol. 2010 Feb 25 628(1-3):171-8. [Content Brief] [5]. Venkatasamy R, et al. Novel relaxant effects of RPL554 on guinea pig tracheal smooth muscle contractility. Br J Pharmacol. 2016 Aug 173(15):2335-51. [Content Brief]
Last Update	2025-04-01 14:45:47

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