SKF 385 hydrochloride MedChemExpress (MCE)

Product Name	Trans-2-Phenylcyclopropylamine Hydrochloride
Synonyms	Tranylcypromine SKF-385 hydrochloride Terephathalic acid monoethyl ester TRANS-2-PHENYLCYCLOPROPANAMINE HCL trans-TranylcyproMine Hydrochloride Trans-2-Phenylcyclopropylamine Hydrochloride Synonyms Tranylcypromine SKF-385 hydrochloride Terephathalic acid monoethyl ester TRANS-2-PHENYLCYCLOPROPANAMINE HCL trans-TranylcyproMine Hydrochloride Trans-2-Phenylcyclopropylamine Hydrochloride rac trans 2-Phenylcyclopropylamine Hydrochloride trans-2-Phenylcyclopropylamine hydrochloride,Tranylcypromine
CAS	1986-47-6
EINECS
Chemical Formula	C9H12ClN
Molecular Weight	169.65
inchi
Package	10 mM * 1 mL;50 mg;100 mg;250 mg
Price	Email to quote
Descriptions	Tranylcypromine hydrochloride Tranylcypromine hydrochloride MedChemExpress (MCE) HY-17447A 1986-47-6 SKF 385 hydrochloride 99.90% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Tranylcypromine hydrochloride Tranylcypromine hydrochloride MedChemExpress (MCE) HY-17447A 1986-47-6 SKF 385 hydrochloride 99.90% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Tranylcypromine hydrochloride (SKF 385 hydrochloride) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC50s of 20.7, 2.3 and 0.95 μM, respectively. Tranylcypromine hydrochloride can be used for the research of depression. Tranylcypromine hydrochlorid (50 μM-5 mM 1 h or 12-14 h) inhibits histone and nucleosomal demethylation[1]. Tranylcypromine hydrochlorid (2 μM 3 h) shows a specific derepression of OCT4 transcription[1]. Tranylcypromine hydrochlorid (0-100 μM 15 min) shows IC50 values of 20.7, 2.3 and 0.95 μM for LSD1, MAO A and MAO B, respectively[2]. Tranylcypromine hydrochlorid (0-800 μM) shows Ki values of 242.7, 101.9 and 16 μM for LSD1, MAO A and MAO B, respectively[2]. Tranylcypromine hydrochlorid (3 mg/kg i.p. once daily for 3 days) decreases LPS-mediated microglial activation and proinflammatory cytokine COX-2 and IL-6 levels in wild-type mice[3]. Tranylcypromine hydrochlorid (3 mg/kg i.p. once daily for 7 days) down-regulates Aβ-mediate microglial activation in 5xFAD mice[3]. MAO-A 2.3 μM (IC50) MAO-B 0.95 μM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Lee MG, et al. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol. 2006 Jun 13(6):563-7. [Content Brief] [2]. Schmidt DM, McCafferty DG. trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry. 2007 Apr 10 46(14):4408-16. [Content Brief] [3]. Park H, et al. The MAO Inhibitor Tranylcypromine Alters LPS- and Aβ-Mediated Neuroinflammatory Responses in Wild-type Mice and a Mouse Model of AD. Cells. 2020 Aug 28 9(9):1982. [Content Brief]
Supplier Website	https://www.medchemexpress.com/tranylcypromine-hydrochloride.html
Last Update	2025-05-21 16:50:25

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