(S)-Sotalol MedChemExpress (MCE)

Product Name	Dexsotalol
Synonyms	Dexsotalol (S)-Sotalol N-[4-[(1S)-1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide Methanesulfonamide, N-[4-[(1S)-1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]- Methanesulfonamide, N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-, (S)- Synonyms Dexsotalol (S)-Sotalol N-[4-[(1S)-1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide Methanesulfonamide, N-[4-[(1S)-1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]- Methanesulfonamide, N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-, (S)- Methanesulfonamide, N-[4-[(1S)-1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]- (9CI)
CAS	30236-32-9
EINECS
Chemical Formula	C12H20N2O3S
Molecular Weight	272.36
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	(+)-Sotalol (+)-Sotalol MedChemExpress (MCE) HY-126028A 30236-32-9 (S)-Sotalol 98.82% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions (+)-Sotalol (+)-Sotalol MedChemExpress (MCE) HY-126028A 30236-32-9 (S)-Sotalol 98.82% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. (+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle. (+)-Sotalol (1, 10, 100 µM) increases in action potential duration in isolated cardiac muscle[2]. (+)-Sotalol (100 μM, 60 minutes) prolongs the action potential in the three cell types (endocardial, epicardial, midmyocardial, and transmural strips)[4]. (+)-Sotalol (8 mg/kg, i.v.) suppresses the induction of ventricular tachyarrhythmias by programmed stimulation in dogs[3]. β-adrenoceptor \| \| \| \| \| \| \| \| \| \| [1]. ChuanjunLu, et al. The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R)-clorprenaline and (S)-sotalol. Tetrahedron: Asymmetry.Volume 22, Issue 7.11 April 2011, Pages 722-727 [2]. Kato R, et al. Electrophysiologic effects of the levo- and dextrorotatory isomers of sotalol in isolated cardiac muscle and their in vivo pharmacokinetics. J Am Coll Cardiol. 1986 Jan 7(1):116-25. [Content Brief] [3]. Lynch JJ, et al. Antiarrhythmic and antifibrillatory actions of the levo- and dextrorotatory isomers of sotalol. J Cardiovasc Pharmacol. 1984 Nov-Dec 6(6):1132-41. [Content Brief] [4]. Serge Sicouri, et al. d-Sotalol Induces Marked Action Potential Prolongation and Early Afterdepolarizations in M but Not Epicardial or Endocardial Cells of the Canine Ventricle. Journal of Cardiovascular Pharmacology and Therapeuticshttps. 2016.
Supplier Website	https://www.medchemexpress.com/plus-sotalol.html
Last Update	2025-05-21 16:50:25

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