AG213 MedChemExpress (MCE)

Product Name	AG 213
Synonyms	AG 213
CAS	122520-86-9
EINECS
Chemical Formula	C10H8N2O2S
Molecular Weight	220.25
inchi
Package	5 mg;10 mg
Price	Email to quote
Descriptions	Tyrphostin AG213 Tyrphostin AG213 MedChemExpress (MCE) HY-101959 122520-86-9 AG213 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Tyrphostin AG213 Tyrphostin AG213 MedChemExpress (MCE) HY-101959 122520-86-9 AG213 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells. Tyrphostin AG213 (25 μM, 50 μM, and 75 μM 24 h, 48 h, and 96 h) increases wound closure time in human umbilical vein endothelial cell (HUVEC) monolayer[1]. Tyrphostin AG213 (100 μM 1 h) interferes with HUVEC focal adhesion and stress fiber formation[1]. Tyrphostin AG213 (100 μM 24 h) inhibits adherence-related tyrosine phosphorylation of pp125FAK in HUVEC[1]. Tyrphostin AG213 (10 μM 24 h) inhibits tyrosine kinase activity, and (4.55-455 mM 24-72 h) inhibits HT-29 cell viability dose- and time-dependently[2]. \| \| \| \| \| \| \| \| \| \| [1]. Romer LH, et al. Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells. Mol Biol Cell. 1994 Mar 5(3):349-61. [Content Brief]
Supplier Website	https://www.medchemexpress.com/tyrphostin-ag213.html
Last Update	2025-05-21 16:50:25

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