PARP-1-IN-4 MedChemExpress (MCE)

Product Name	N-(4-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]acetamide
Synonyms	N-(4-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]acetamide;N-(4-Chlorophenyl)-2-(4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl)acetamide
CAS	684234-56-8
EINECS
Chemical Formula	C22H15Cl2N3O2
Molecular Weight	424.28
inchi
Package	5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	PARP-1-IN-4 PARP-1-IN-4 MedChemExpress (MCE) HY-153590 684234-56-8 99.74% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions PARP-1-IN-4 PARP-1-IN-4 MedChemExpress (MCE) HY-153590 684234-56-8 99.74% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. PARP-1-IN-4 is a PARP-1 inhibitor. PARP-1-IN-4 has inhibitory activity against PARP-1 with IC50 value of 302 μM. PARP-1-IN-4 can be used for the research of lung adenocarcinoma. PARP-1-IN-4 has inhibitory activity against PARP-1 with IC50 value of 302 μM[1]. PARP-1-IN-4 (0.1, 1 and 10 μM 24h and 48h) has cytotoxicity activity against A549 cells[1]. PARP-1-IN-4 (1 μM 24h) exhibits a significant increase in the expression levels of caspase-3 and caspase-9protein[1]. IC50: 302 μM (PARP-1)[1] In Vitro PARP-1-IN-4 has inhibitory activity against PARP-1 with IC50 value of 302 μM[1]. PARP-1-IN-4 (0.1, 1 and 10 μM 24h and 48h) has cytotoxicity activity against A549 cells[1]. PARP-1-IN-4 (1 μM 24h) exhibits a significant increase in the expression levels of caspase-3 and caspase-9protein[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PARP-1-IN-4 Related Antibodies Cell Proliferation Assay[1] Cell Line: A549 cells \| \| \| \| \| \| \| \| \| \| [1]. Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 77:443-456. [Content Brief]
Last Update	2025-04-01 14:45:47

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