CL2A-SN-38 MedChemExpress (MCE)

Product Name	CL2A-SN-38
Synonyms	CL2A-SN-38 [4-[[(2S)-2-(4-Aminobutyl)-35-[4-[[[[4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexyl]carbonyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-1,4,8-trioxo-6,12,15,18,21,24,27,30,33-nonaoxa-3,9-diazapentatriacont-1-yl]amino]phenyl]methyl(4S)-4,11-diethyl-3 Synonyms CL2A-SN-38 [4-[[(2S)-2-(4-Aminobutyl)-35-[4-[[[[4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexyl]carbonyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-1,4,8-trioxo-6,12,15,18,21,24,27,30,33-nonaoxa-3,9-diazapentatriacont-1-yl]amino]phenyl]methyl(4S)-4,11-diethyl-3 Carbonic acid, [4-[[(2S)-2-(4-aminobutyl)-35-[4-[[[[4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexyl]carbonyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-1,4,8-trioxo-6,12,15,18,21,24,27,30,33-nonaoxa-3,9-diazapentatriacont-1-yl]amino]phenyl]methyl (4S)-4,11-diethyl-3,4,12,14-tetrahydro-9-hydroxy...
CAS	1279680-68-0
EINECS	604-604-1
Chemical Formula	C73H97N11O22
Molecular Weight	1480.63
inchi
Package	5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	CL2A-SN-38 CL2A-SN-38 MedChemExpress (MCE) HY-128946 1279680-68-0 99.07% -20°C, stored under nitrogen In solvent : -80°C, 6 months Descriptions CL2A-SN-38 CL2A-SN-38 MedChemExpress (MCE) HY-128946 1279680-68-0 99.07% -20°C, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (stored under nitrogen) Room temperature in continental US may vary elsewhere. CL2A-SN-38 is a agent-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody agent conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A-SN-38 uses hydrolyzable linker to deliver active agents within tumor cells and in the tumor microenvironment, resulting in bystander effects. CL2A-SN-38 coupled to the anti-Trop-2 humanized antibody hRS7 (intraperitoneal injection, 0.2 or 0.4 mg/kg, twice weekly, 4 weeks) can both significantly inhibit tumor growth in mice with human colon (COLO 205) or pancreatic (Capan-1) tumour xenografts[2]. Camptothecins \| \| \| \| \| \| \| \| \| \| [1]. Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15 17(10):3157-69. [Content Brief] [2]. Thomas M Cardillo, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15 17(10):3157-69. [Content Brief]
Supplier Website	https://www.medchemexpress.com/cl2a-sn-38.html
Last Update	2025-05-21 16:50:25

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