5-Fluorouridine MedChemExpress (MCE)

Product Name	5-Fluorouridine
Synonyms	FURD 5-fur FLUOROURIDINE 5-fluoro-uridin 5-Fluorouridine Uridine, 5-fluoro- Synonyms FURD 5-fur FLUOROURIDINE 5-fluoro-uridin 5-Fluorouridine Uridine, 5-fluoro- 5-Fluorouracil-1beta-D-ribofuranoside 5-fluoro-1-beta-L-ribofuranosylpyrimidine-2,4(1H,3H)-dione 1-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-5-fluoropyrimidine-2,4-dione 1-(3,4-DIHYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-5-FLUORO-1H-PYRIMIDINE-2,4-DIONE 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1
CAS	316-46-1;77180-80-4
EINECS	206-260-3
Chemical Formula	C9H11FN2O6
Molecular Weight	262.19
inchi	InChI=1/C9H11FN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m0/s1
Package	10 mM * 1 mL;50 mg;100 mg
Price	Email to quote
Descriptions	5-Fluorouridine 5-Fluorouridine MedChemExpress (MCE) HY-107856 316-46-1 99.75% 4°C, stored under nitrogen In solvent : -80°C, 6 months Descriptions 5-Fluorouridine 5-Fluorouridine MedChemExpress (MCE) HY-107856 316-46-1 99.75% 4°C, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (stored under nitrogen) Room temperature in continental US may vary elsewhere. 5-Fluorouridine, a metabolite of 5-fluorouracil (HY-90006), is a potent ribozyme self-cleavage inhibitor. 5-Fluorouridine incorporates into both total and poly A RNA and has antiproliferative activity. 5-Fluorouridine induces apoptosis. 5-Fluorouridine (167 μM 24-96 h) inhibits MKN45 cells and MKN28 cells in a time-dependent manner[1]. 5-Fluorouridine (10 μM 24 h HCT-116 cells) induces apoptosis and increases the percentage of apoptotic cells. 5-Fluorouridine upregulates the expression of 33 genes, including a group of genes as growth factors, cytokines and chemokines (e.g. IL-3, IL -4, B-cell growth factor 1 and stem cell growth factor)[2]. 5-Fluorouridine (10 μM 8-24 h HCT-116 cells) incorporates into both total and poly A RNA[2]. 5-Fluorouridine (567-1500 mg/kg i.p. daily, for 20 d) induce gastrointestinal toxicity in the mice[3]. \| \| \| \| \| \| \| \| \| \| [1]. Wu FL, et, al. Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2'-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics. Cancer Lett. 2015 Jul 10 363(1):7-16. [Content Brief] [2]. Schmittgen TD, et, al. Diverse gene expression pattern during 5-fluorouridine-induced apoptosis. Int J Oncol. 2005 Aug 27(2):297-306. [Content Brief] [3]. Houghton JA, et, al. Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine. Cancer Res. 1979 Jul 39(7 Pt 1):2406-13. [Content Brief]
Last Update	2025-04-01 14:45:47

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