WHI-P258 MedChemExpress (MCE)

Product Name	4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE
Synonyms	WHIP258 WHI P258 WHI-P258 JAK3 INHIBITOR NEGATIVE CONTROL JAK3 INHIBITOR, NEGATIVE CONTROL 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE 6,7-DIMETHOXY-N-PHENYL-4-QUINAZOLINAMINE Synonyms WHIP258 WHI P258 WHI-P258 JAK3 INHIBITOR NEGATIVE CONTROL JAK3 INHIBITOR, NEGATIVE CONTROL 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE 6,7-DIMETHOXY-N-PHENYL-4-QUINAZOLINAMINE 6,7-dimethoxy-N-phenylquinazolin-4-amine 4-Quinazolinamine, 6,7-dimethoxy-N-phenyl- N-(6,7-DIMETHOXY-4-QUINAZOLINYL)-N-PHENYLAMINE
CAS	21561-09-1
EINECS
Chemical Formula	C16H15N3O2
Molecular Weight	281.31
inchi
Package	1 mg;2 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	WHI-P258 WHI-P258 MedChemExpress (MCE) HY-108419 21561-09-1 99.61% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions WHI-P258 WHI-P258 MedChemExpress (MCE) HY-108419 21561-09-1 99.61% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM. \| \| \| \| \| \| \| \| \| \| [1]. Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun 5(6):1569-82. [Content Brief] [2]. Tibbles HE, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001 May 25 276(21):17815-22. [Content Brief]
Last Update	2025-04-01 14:45:47

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