BC-3781 acetate MedChemExpress (MCE)

Product Name	WSMXIQXWHPSVDE-WHAUHWDVSA-N
Synonyms	BC-3781 ACETATE;Lefamulin acetate;WSMXIQXWHPSVDE-WHAUHWDVSA-N
CAS	1350636-82-6
EINECS	208-388-5
Chemical Formula	C30H49NO7S
Molecular Weight	567.78
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Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	Lefamulin acetate Lefamulin acetate MedChemExpress (MCE) HY-16908A 1350636-82-6 BC-3781 acetate 98.76% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Lefamulin acetate Lefamulin acetate MedChemExpress (MCE) HY-16908A 1350636-82-6 BC-3781 acetate 98.76% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Lefamulin (BC-3781) acetate is an orally active antibiotic. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin acetate has anti-inflammatory activity. Lefamulin acetate can be used in the research of bacterial infections, such as bacterial pneumonia. Lefamulin (0-1 mg/L) acetate shows inhibitory activity against C. trachomatis, N. gonorrhoeae, and M. genitalium[2]. Lefamulin acetate shows potent activity against all M. pneumoniae strains with MIC values of ≤0.008 μg/mL[3]. Lefamulin (10-140 mg/kg, s.c.) acetate shows anti-inflammatory effect on LPS-induced lung neutrophilia mouse model[4]. Lefamulin (1.25-160 mg/kg, s.c.) acetate shows antibacterial effect in S. pneumoniae or S. aureus challenged lung infection mice[5]. \| \| \| \| \| \| \| \| \| \| [1]. Veve MP, et al. Lefamulin: Review of a Promising Novel Pleuromutilin Antibiotic. Pharmacotherapy. 2018 Sep 38(9):935-946. doi: 10.1002/phar.2166. Epub 2018 Aug 20. [Content Brief] [2]. Susanne Paukner, et al. Antimicrob Agents Chemother. 2018 Apr 26 62(5):e02380-17. [Content Brief] [3]. Ken B Waites, et al. In Vitro Activities of Lefamulin and Other Antimicrobial Agents against Macrolide-Susceptible and Macrolide-Resistant Mycoplasma pneumoniae from the United States, Europe, and China. Antimicrob Agents Chemother. 2017 Jan 24 61(2):e02008-16. [Content Brief] [4]. Michael Hafner, et al. Anti-inflammatory activity of lefamulin versus azithromycin and dexamethasone in vivo and in vitro in a lipopolysaccharide-induced lung neutrophilia mouse model. PLoS One. 2021 Sep 29 16(9): e0237659. [Content Brief] [5]. Wolfgang W Wicha, et al. Pharmacokinetics/pharmacodynamics of lefamulin in a neutropenic murine pneumonia model with Staphylococcus aureus and Streptococcus pneumonia. J Antimicrob Chemother. 2019 Apr 1 74(Suppl 3):iii11-iii18. [Content Brief]
Supplier Website	https://www.medchemexpress.com/lefamulin-acetate.html
Last Update	2025-05-21 16:50:25

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