3-Hydroxy agomelatine MedChemExpress (MCE)

Product Name	3-Hydroxy Agomelatine
Synonyms	3-Hydroxy Agomelatine
CAS	166526-99-4
EINECS
Chemical Formula	C15H17NO3
Molecular Weight	259.30038
inchi
Package	10 mM * 1 mL;5 mg;10 mg
Price	Email to quote
Descriptions	3-Hydroxy agomelatine 3-Hydroxy agomelatine MedChemExpress (MCE) HY-133111 166526-99-4 98.00% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions 3-Hydroxy agomelatine 3-Hydroxy agomelatine MedChemExpress (MCE) HY-133111 166526-99-4 98.00% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. 3-Hydroxy agomelatine is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM. Agomelatine and S 21517 have moderately high affinities for 5-HT2C receptors (Ki = 0.21 μM and 0.13 μM, respectively). The metabolite 3-Hydroxy agomelatine (S 21540) has a 10-fold lower affinity (Ki = 1.8 μM). Agomelatine, S 21517 and 3-Hydroxy agomelatine (10-7-10-4 M) are antagonists at 5-HT2C receptors, with a rank order of efficacy as follows: S 21517>Agomelatine>3-Hydroxy agomelatine[1]. Increasing doses (from 1.25 to 40 mg/kg, intraperitoneal injection) of 3-Hydroxy agomelatine (S 21540) does not affect the penile erections induced by mCPP and Ro 60-0175 in Wistar rat[1]. 5-HT2C Receptor 3.2 μM (IC50) 5-HT2C Receptor 1.8 μM (Ki) \| \| \| \| \| \| \| \| \| \| [1]. Chagraoui A, et al. Agomelatine(S 20098) antagonizes the penile erections induced by the stimulation of 5-HT2C receptors in Wistar rats. Psychopharmacology (Berl). 2003 Oct 170(1):17-22. [Content Brief]
Supplier Website	https://www.medchemexpress.com/3-hydroxy-agomelatine.html
Last Update	2025-05-21 16:50:25

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