MET-88; Quaterin MedChemExpress (MCE)

Product Name	MILDRONATE
Synonyms	MET88 Kvaterin Quateri MILDRONATE Mildonate Meldomiun 3-(trimethylammonioamino)propanoate Synonyms MET88 Kvaterin Quateri MILDRONATE Mildonate Meldomiun 3-(trimethylammonioamino)propanoate 3-(trimethylammonioamino)propionate 3-(trimethylazaniumylamino)propanoate 3-(2,2,2-trimethylhydrazine)propionate 3-(2,2,2-trimethylhydrazine)propionate 3-(2,2,2-Trimethylhydrazinium)propionate 3-(2,2,2-triMethylhydraziniuM)propionate dehydrate Mildronate 3-(2,2,2-Trimethylhydrazine)propionate 3-(2,2,2-trimethyldiazan-2-iumyl)propanoate dihydrate 2-(2-Carboxyethyl)-1,1,1-trimethyl Hydrazinium Inner Salt 2-(2-carboxyethyl)-1,1,1-trimethylhydrazinium hydroxide inner salt 2-(2-carboxyethyl)-1,1,1-trimethylhydrazinium hydroxide inner salt
CAS	76144-81-5
EINECS	682-135-0
Chemical Formula	C6H14N2O2
Molecular Weight	146.19
inchi	InChI=1/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5?,6-,7-,8?/m1/s1
Package	10 mM * 1 mL;50 mg;100 mg
Price	Email to quote
Descriptions	Meldonium Meldonium MedChemExpress (MCE) HY-B1836 76144-81-5 MET-88 Descriptions Meldonium Meldonium MedChemExpress (MCE) HY-B1836 76144-81-5 MET-88 Quaterin 99.82% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Meldonium (MET-88) functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium is a fatty acid oxidation inhibitor. Meldonium (20-40 μM 24 h) ameliorates lung injury by targeting PFKP to regulate glycolysis, which promotes Nrf2 translocation from the cytoplasm to the nucleus to alleviate oxidative stress and mitochondrial damage under hypoxic condition[3]. Meldonium (50, 100, or 200 mg/kg once daily for 3 days) modestly attenuates hypoxia-induced lung injury in mice[3]. IC50: 34-62 μM (human recombinant BBOX). EC50: 21 μM (human OCTN2). In Vitro Meldonium (20-40 μM 24 h) ameliorates lung injury by targeting PFKP to regulate glycolysis, which promotes Nrf2 translocation from the cytoplasm to the nucleus to alleviate oxidative stress and mitochondrial damage under hypoxic condition[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Meldonium Related Antibodies RT-PCR[3] Cell Line: Rat alveolar type II epithelial RLE-6TN cells in hypoxia incubator \| \| \| \| \| \| \| \| \| \| [1]. Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov 113(Pt B):771-780. [Content Brief] [2]. Jolanta Pupure, et al. Neuroprotective properties of mildronate, a mitochondria-targeted small molecule. Neurosci Lett. 2010 Feb 12 470(2):100-5. [Content Brief] [3]. Daohui Wang, et al. Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis. Front Pharmacol. 2022 Apr 5:13:863451. [Content Brief]
Supplier Website	https://www.medchemexpress.com/meldonium.html
Last Update	2025-05-21 16:50:25

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