N-Acetyl-S-farnesyl-L-cysteine MedChemExpress (MCE)

Product Name	AFC
Synonyms	AFC AC-CYS(FARNESYL)-OH AC-CYSTEINE(FARNESYL)-OH n-acetyl-s-farnesylcysteine ACETYL-S-FARNESYL-L-CYSTEINE N-ACETYL-S-FARNESYL-L-CYSTEINE N-ALPHA-ACETYL-S-FARNESYL-L-CYSTEINE Synonyms AFC AC-CYS(FARNESYL)-OH AC-CYSTEINE(FARNESYL)-OH n-acetyl-s-farnesylcysteine ACETYL-S-FARNESYL-L-CYSTEINE N-ACETYL-S-FARNESYL-L-CYSTEINE N-ALPHA-ACETYL-S-FARNESYL-L-CYSTEINE N-ACETYL-S-(3,7,11-TRIMETHYL-2E,6E,10-DODECATRIENYL)-L-CYSTEINE
CAS	135304-07-3
EINECS
Chemical Formula	C20H33NO3S
Molecular Weight	367.55
inchi
Package	1 mg (27.2 mM * 100 μL in Methyl acetate);5 mg (27.2 mM * 500 μL in Methyl acetate)
Price	Email to quote
Descriptions	Arazine Arazine MedChemExpress (MCE) HY-133021 135304-07-3 N-Acetyl-S-farnesyl-L-cysteine 98.0% Solution, -20°C, 2 years Room temperature in continental US Descriptions Arazine Arazine MedChemExpress (MCE) HY-133021 135304-07-3 N-Acetyl-S-farnesyl-L-cysteine 98.0% Solution, -20°C, 2 years Room temperature in continental US may vary elsewhere. Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell[1]. Arazine (10–100 μM 8 hours) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell[1]. Arazine (AFC) (2,000?μg/20?μl applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED50) of 55±12?μg/20?μl[1]. \| \| \| \| \| \| \| \| \| \| [1]. Gordon JS, et al. Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site.J Invest Dermatol. 2008 Mar 128(3):643-54. Epub 2007 Sep 20. [Content Brief] [2]. Adhami K, et al. N-acetyl-S-farnesyl-l-cysteine suppresses chemokine production by human dermal microvascular endothelial cells.Exp Dermatol. 2012 Sep 21(9):700-5. [Content Brief]
Last Update	2025-04-01 14:45:47

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