CC-90009 MedChemExpress (MCE)

Product Name	CC-90009
Synonyms	CC-90009; CC90009; CC 90009;Eragidomide;Cereblon modulator 1;CEREBLON MODULATOR 1;Benzeneacetamide, 4-chloro-N-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-α,α-difluoro-
CAS	1860875-51-9
EINECS
Chemical Formula	C22H18ClF2N3O4
Molecular Weight	461.85
inchi
Package	1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Eragidomide Eragidomide MedChemExpress (MCE) HY-130800 1860875-51-9 CC-90009 99.76% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Eragidomide Eragidomide MedChemExpress (MCE) HY-130800 1860875-51-9 CC-90009 99.76% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation. Depletion of GSPT1 by Eragidomide rapidly induces acute myeloid leukemia (AML) apoptosis, reducing leukemia engraftment and leukemia stem cells (LSCs) in large-scale primary patient xenografting of 35 independent AML samples. Eragidomide activity is mediated by multiple layers of signaling networks and pathways within AML blasts and LSCs[1]. Cereblon \| \| \| \| \| \| \| \| \| \| [1]. Christine Surka, et al. CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood. 2021 Feb 4 137(5):661-677. [Content Brief] [2]. Joshua D Hansen, et al. CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2021 Feb 25 64(4):1835-1843. [Content Brief]
Last Update	2025-04-01 14:45:47

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