NTRC-824 MedChemExpress (MCE)

Product Name	SOOLLEBJNGCDOZ-FQEVSTJZSA-N
Synonyms	NTRC 824;SOOLLEBJNGCDOZ-FQEVSTJZSA-N;N-[2-[5-[[(4-Methylphenyl)sulfonyl]amino]-3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl]acetyl]-L-leucine
CAS	1623002-61-8
EINECS
Chemical Formula	C25H26F3N3O6S
Molecular Weight	553.55
inchi
Package	1 mg
Price	Email to quote
Descriptions	NTRC-824 NTRC-824 MedChemExpress (MCE) HY-12436 1623002-61-8 98.2% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions NTRC-824 NTRC-824 MedChemExpress (MCE) HY-12436 1623002-61-8 98.2% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC50 of 38 nM and a Ki of 202 nM. NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM). Testing of NTRC-824 (Compound 5) at the NTS1 receptor shows no binding activity in the NTS1 assay up to 30 μM, making NTRC-824 (Compound 5) selective for NTS2 in both the binding and functional assays. NTRC-824 (Compound 5) is the first nonpeptide compound that behaves like, and is more active than, the endogenous ligand[1]. IC50: 38 nM (Nurotensin receptor type 2)[1] Ki: 202 nM (Nurotensin receptor type 2)[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Thomas JB, et al. Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2. J Med Chem. 2014 Sep 11 57(17 [Content Brief]
Last Update	2025-04-01 14:45:47

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